Shifting senescence into quiescence by turning up p53

被引:33
作者
Serrano, Manuel [1 ]
机构
[1] Spanish Natl Canc Res Ctr CNIO, Tumor Suppress Grp, Madrid, Spain
基金
欧洲研究理事会;
关键词
CELLULAR SENESCENCE; STRESS;
D O I
10.4161/cc.9.21.13785
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:4256 / 4257
页数:2
相关论文
共 12 条
[1]   A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis [J].
Alimonti, Andrea ;
Nardella, Caterina ;
Chen, Zhenbang ;
Clohessy, John G. ;
Carracedo, Arkaitz ;
Trotman, Lloyd C. ;
Cheng, Ke ;
Varmeh, Shohreh ;
Kozma, Sara C. ;
Thomas, George ;
Rosivatz, Erika ;
Woscholski, Rudiger ;
Cognetti, Francesco ;
Scher, Howard I. ;
Pandolfi, Pier Paolo .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (03) :681-693
[2]   p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling [J].
Budanov, Andrei V. ;
Karin, Michael .
CELL, 2008, 134 (03) :451-460
[3]   Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [J].
Budanov, AV ;
Sablina, AA ;
Feinstein, E ;
Koonin, EV ;
Chumakov, PM .
SCIENCE, 2004, 304 (5670) :596-600
[4]   mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging [J].
Castilho, Rogerio M. ;
Squarize, Cristiane H. ;
Chodosh, Lewis A. ;
Williams, Bart O. ;
Gutkind, J. Silvio .
CELL STEM CELL, 2009, 5 (03) :279-289
[5]   Cellular senescence in cancer and aging [J].
Collado, Manuel ;
Blasco, Maria A. ;
Serrano, Manuel .
CELL, 2007, 130 (02) :223-233
[6]   SENESCENCE Senescence in tumours: evidence from mice and humans [J].
Collado, Manuel ;
Serrano, Manuel .
NATURE REVIEWS CANCER, 2010, 10 (01) :51-57
[7]   Growth stimulation leads to cellular senescence when the cell cycle is blocked [J].
Demidenko, Zoya N. ;
Blagosklonny, Mikhail V. .
CELL CYCLE, 2008, 7 (21) :3355-3361
[8]   Paradoxical suppression of cellular senescence by p53 [J].
Demidenko, Zoya N. ;
Korotchkina, Lioubov G. ;
Gudkov, Andrei V. ;
Blagosklonny, Mikhail V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (21) :9660-9664
[9]   The regulation of AMPK β1, TSC2, and PTEN expression by p53:: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways [J].
Feng, Zhaohui ;
Hu, Wenwei ;
de Stanchina, Elisa ;
Teresky, Angelika K. ;
Jin, Shengkan ;
Lowe, Scott ;
Levine, Arnold J. .
CANCER RESEARCH, 2007, 67 (07) :3043-3053
[10]   Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a) [J].
Serrano, M ;
Lin, AW ;
McCurrach, ME ;
Beach, D ;
Lowe, SW .
CELL, 1997, 88 (05) :593-602