Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

被引：48

作者：

Osipyan, Angelina ^{[1
]}

Chen, Deng ^{[1
]}

Dekker, Frank J. ^{[1
]}

机构：

[1] Univ Groningen, Groningen Res Inst Pharm GRIP, Dept Chem & Pharmaceut Biol, NL-9713 AV Groningen, Netherlands

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 07期

关键词：

NF-KAPPA-B; HISTONE DEACETYLASE INHIBITORS; FACTOR MIF; RHEUMATOID-ARTHRITIS; EXPRESSION; GENE; PHOSPHORYLATION; INVOLVEMENT; INVASION; HYPOXIA;

D O I：

10.1016/j.drudis.2021.03.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Epigenetic mechanisms are important for the regular development and maintenance of the tissuespecific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

引用

页码：1728 / 1734

页数：7

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