A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins

被引：250

作者：

Hackbusch, J ^{[1
]}

Richter, K ^{[1
]}

Müller, J ^{[1
]}

Salamini, F ^{[1
]}

Uhrig, JF ^{[1
]}

机构：

[1] Max Planck Inst Zuchtungsforsch, D-50829 Cologne, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 13期

关键词：

cytoskeleton; network modules; protein-protein interactions; BELL proteins; KNOX proteins;

D O I：

10.1073/pnas.0501181102

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The organization of living cells is based on networks of interacting molecules. Systematic analysis of protein interactions of 3-aa loop extension (TALE) homeodomain proteins, fundamental regulators of plant meristem function and leaf development, revealed a highly connected, complex network. The network includes nine members of Arabidopsis thaliana ovate family proteins (AtOFPs), a plant-specific protein family, indicating a close functional connection to TALE homeodomain proteins. Evidence is provided that AtOFP1 is an essential pleiotropic developmental regulator. AtOFP1 and AtOFP5 are shown to associate with the cytoskeleton and to regulate subcellular localization of TALE homeodomain proteins, suggesting a previously unrecognized control mechanism in plant development.

引用

页码：4908 / 4912

页数：5

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