Incidence of the Fuld WAIS-R profile in traumatic brain injury and Parkinson's disease

The frequency of occurrence of the Fuld profile for cholinergic deficiency was investigated in two clinical populations. inpatients who had suffered traumatic brain injury and outpatients who carried a diagnosis of Parkinson's disease. The observed incidence of positive Fuld profiles was not significantly different in rite two groups, 14% in rile traumatic brain injury group and 24% in the Parkinson Is disease group. These findings are consistent with recent reviews of rile sensitivity and specificity of the Fuld profile in various clinical and nonclinical populations. The generally sensitivity of the Fuld profile does riot support its usefulness il the differential diagnosis of dementia. However, ii may serve as an indicator of cholinergic deficient which could be used to select patients who would be likely ro respond io cholinomimetic therapies. (C) 1998 National Academy of Neuropsychology. Published by Elsevier Science Ltd.