Optical manipulation: advances for biophotonics in the 21st century

被引:29
作者
Corsetti, Stella [1 ]
Dholakia, Kishan [1 ,2 ,3 ]
机构
[1] Univ St Andrews, Sch Phys & Astron, SUPA, St Andrews, Fife, Scotland
[2] Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia
[3] Yonsei Univ, Coll Sci, Dept Phys, Seoul, South Korea
基金
英国工程与自然科学研究理事会;
关键词
optical manipulation; optical tweezers; trapping; optics; biophotonics; light; MOLECULE FORCE SPECTROSCOPY; SINGLE-MOLECULE; MELTING BUBBLES; RNA-POLYMERASE; PEELED SSDNA; S-DNA; CELLS; TWEEZERS; LIGHT; TRAP;
D O I
10.1117/1.JBO.26.7.070602
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Significance: Optical trapping is a technique capable of applying minute forces that has been applied to studies spanning single molecules up to microorganisms. Aim: The goal of this perspective is to highlight some of the main advances in the last decade in this field that are pertinent for a biomedical audience. Approach: First, the direct determination of forces in optical tweezers and the combination of optical and acoustic traps, which allows studies across different length scales, are discussed. Then, a review of the progress made in the direct trapping of both single-molecules, and even single-viruses, and single cells with optical forces is outlined. Lastly, future directions for this methodology in biophotonics are discussed. Results: In the 21st century, optical manipulation has expanded its unique capabilities, enabling not only a more detailed study of single molecules and single cells but also of more complex living systems, giving us further insights into important biological activities. Conclusions: Optical forces have played a large role in the biomedical landscape leading to exceptional new biological breakthroughs. The continuous advances in the world of optical trapping will certainly lead to further exploitation, including exciting in-vivo experiments. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.
引用
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页数:23
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