The increasing complexity of the ubiquitin code

被引：830
作者：
Yau, Richard [1 ,2 ]
Rape, Michael [1 ,2 ]
机构：
[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
来源：
NATURE CELL BIOLOGY | 2016年 / 18卷 / 06期
基金：
美国国家卫生研究院;
关键词：
ANAPHASE-PROMOTING COMPLEX; RETICULUM-ASSOCIATED DEGRADATION; UNANCHORED POLYUBIQUITIN CHAINS; MITOCHONDRIAL QUALITY-CONTROL; KAPPA-B ACTIVATION; END RULE PATHWAY; MULTIUBIQUITIN CHAIN; DNA-DAMAGE; DEUBIQUITINATING ENZYME; SUBSTRATE DEGRADATION;
D O I：
10.1038/ncb3358
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ubiquitylation is essential for signal transduction as well as cell division and differentiation in all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex polymeric chains, with different types of ubiquitylation often eliciting distinct outcomes. The recent identification of novel chain topologies has improved our understanding of how ubiquitylation establishes precise communication within cells. Here, we discuss how the increasing complexity of ubiquitylation is employed to ensure robust and faithful signal transduction in eukaryotic cells.
引用
收藏
页码：579 / 586
页数：8
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