Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

被引：99

作者：

de Witte, Lot ^{[1
]}

Nabatov, Alexey ^{[1
]}

Geijtenbeek, Teunis B. H. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

来源：

TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.molmed.2007.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present., the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission.

引用

页码：12 / 19

页数：8

共 55 条

[1]

[Anonymous], 2005, AIDS Policy Law, V20, P1

[2] DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells [J].

Arrighi, JF ;

Pion, M ;

Garcia, E ;

Escola, JM ;

van Kooyk, Y ;

Geijtenbeek, TB ;

Piguet, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (10) :1279-1288

[3] Analysis of total human immunodeficiency virus (HIV)-specific CD4+ and CD8+ T-cell responses:: Relationship to viral load in untreated HIV infection [J].

Betts, MR ;

Ambrozak, DR ;

Douek, DC ;

Bonhoeffer, S ;

Brenchley, JM ;

Casazza, JP ;

Koup, RA ;

Picker, LJ .

JOURNAL OF VIROLOGY, 2001, 75 (24) :11983-11991

[4] Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN [J].

Boggiano, Cesar ;

Manel, Nicolas ;

Littman, Dan R. .

JOURNAL OF VIROLOGY, 2007, 81 (05) :2519-2523

[5] Infection of dendritic cells (DCs), not DC-SIGN-mediated internalization of human immunodeficiency virus, is required for long-term transfer of virus to T cells [J].

Burleigh, L ;

Lozach, PY ;

Schiffer, C ;

Staropoli, I ;

Pezo, V ;

Porrot, F ;

Canque, B ;

Virelizier, JL ;

Arenzana-Seisdedos, F ;

Amara, A .

JOURNAL OF VIROLOGY, 2006, 80 (06) :2949-2957

[6] MHC-I-restricted presentation of HIV-1 virion antigens without viral replication [J].

Buseyne, F ;

Le Gall, S ;

Boccaccio, C ;

Abastado, JP ;

Lifson, JD ;

Arthur, LO ;

Rivière, Y ;

Heard, JM ;

Schwartz, O .

NATURE MEDICINE, 2001, 7 (03) :344-349

[7] In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions [J].

Cavrois, Marielle ;

Neidleman, Jason ;

Kreisberg, Jason F. ;

Greene, Warner C. .

PLOS PATHOGENS, 2007, 3 (01) :38-45

[8] Langerin is a natural barrier to HIV-1 transmission by Langerhans cells [J].

de Witte, Lot ;

Nabatov, Alexey ;

Pion, Marjorie ;

Fluitsma, Donna ;

de Jong, Marein A. W. P. ;

de Gruijl, Tanja ;

Piguet, Vincent ;

van Kooyk, Yvette ;

Geijtenbeek, Teunis B. H. .

NATURE MEDICINE, 2007, 13 (03) :367-371

[9]

DEWITTE L, IN PRESS P NATL ACAD

[10] Activated CD34-derived langerhans cells mediate transinfection with human immunodeficiency virus [J].

Fahrbach, Kelly M. ;

Barry, Sheila M. ;

Ayehunie, Seyourn ;

Lamore, Sarah ;

Klausner, Mitchell ;

Hope, Thomas J. .

JOURNAL OF VIROLOGY, 2007, 81 (13) :6858-6868

← 1 2 3 4 5 6 →