Ischemia modified albumin changes - review and clinical implications

被引：164

作者：

Sbarouni, Eftihia ^{[1
]}

Georgiadou, Panagiota ^{[1
]}

Voudris, Vassilis ^{[1
]}

机构：

[1] Onassis Cardiac Surg Ctr, Dept Cardiol 2, Athens 17674, Greece

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2011年 / 49卷 / 02期

关键词：

biomarkers; ischemia; ischemia modified albumin; PERCUTANEOUS CORONARY INTERVENTION; ELEVATION MYOCARDIAL-INFARCTION; SKELETAL-MUSCLE ISCHEMIA; HUMAN SERUM-ALBUMIN; COBALT-BINDING TEST; RADIOFREQUENCY CATHETER ABLATION; CARDIAC TROPONIN-T; EMERGENCY-DEPARTMENT; CHEST-PAIN; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1515/CCLM.2011.037

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Ischemia modified albumin (IMA), as measured using the albumin cobalt binding test, is currently the most promising biomarker for early detection of ischemia before the onset of irreversible cardiac injury. This paper reviews the information available on IMA, including its pathophysiology, analysis, clinical applications and future perspectives. The data provided was identified by a search of MEDLINE using the terms IMA, biomarkers and ischemia. IMA may be useful to cover the complete diagnostic window of patients presenting with acute coronary syndromes (ACS) in the Emergency Department, along with the electrocardiogram and cardiac troponins. Preliminary data regarding the significance of IMA in the prognosis of either ACS or following revascularization need further study.

引用

页码：177 / 184

页数：8

共 81 条

[1] Ischemia-modified albumin in acute stroke [J].

Abboud, Halim ;

Labreuche, Julien ;

Meseguer, Elena ;

Lavallee, Philippa C. ;

Simon, Olivier ;

Olivot, Jean-Marc ;

Mazighi, Mikael ;

Dehoux, Monique ;

Benessiano, Joelle ;

Steg, Philippe Gabriel ;

Amarenco, Pierre .

CEREBROVASCULAR DISEASES, 2007, 23 (2-3) :216-220

[2] EVALUATION OF A RAPID BEDSIDE ASSAY FOR DETECTION OF SERUM CARDIAC TROPONIN-T [J].

ANTMAN, EM ;

GRUDZIEN, C ;

SACKS, DB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (16) :1279-1282

[3]

Anwaruddin S, 2005, AM J CLIN PATHOL, V123, P140

[4] Prognostic significance of ischemia-modified albumin in patients with acute coronary syndrome [J].

Aparci, Mustafa ;

Kardesoglu, Ejder ;

Ozmen, Namik ;

Ozcan, Oemer ;

Cebeci, Bekir Sitki ;

Cingozbay, Bekir Yilmaz ;

Dincturk, Mehmet .

CORONARY ARTERY DISEASE, 2007, 18 (05) :367-373

[5] Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome [J].

Apple, FS ;

Wu, AHB ;

Mair, J ;

Ravkilde, J ;

Panteghini, M ;

Tate, J ;

Pagani, F ;

Christenson, RH ;

Mockel, M ;

Danne, O ;

Jaffe, AS .

CLINICAL CHEMISTRY, 2005, 51 (05) :810-824

[6]

Apple FS, 2002, CLIN CHEM, V48, P1097

[7] Ischemia modified albumin measured by the albumin cobalt binding test: A clinical and analytical review [J].

Aslan, D ;

Apple, FS .

LABORATORY MEDICINE, 2004, 35 (01) :44-47

[8] Prognostic value of ischaemia-modified albumin in patients with non-ST-segment elevation acute coronary syndromes [J].

Bali, Laurent ;

Cuisset, Thomas ;

Giorgi, Roch ;

Monserrat, Colette ;

Quilici, Jacques ;

Carrega, Louis ;

Mouret, Jean-Philippe ;

Nait-Saidi, Lyassine ;

Mielot, Christopher ;

Lambert, Marc ;

Guieu, Regis ;

Bonnet, Jean-Louis .

ARCHIVES OF CARDIOVASCULAR DISEASES, 2008, 101 (10) :645-651

[9] A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia - A preliminary report [J].

Bar-Or, D ;

Lau, E ;

Winkler, JV .

JOURNAL OF EMERGENCY MEDICINE, 2000, 19 (04) :311-315

[10] Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: A preliminary comparison to creatine kinase-MB, myoglobin, and troponin I [J].

Bar-Or, D ;

Winkler, JV ;

VanBenthuysen, K ;

Harris, L ;

Lau, E ;

Hetzel, FW .

AMERICAN HEART JOURNAL, 2001, 141 (06) :985-991

← 1 2 3 4 5 6 7 8 9 →