New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019

被引：26

作者：

Cucco, Lucilla ^{[1
]}

Paniccia, Marta ^{[1
]}

Massacci, Francesca Romana ^{[1
]}

Morelli, Alessandra ^{[1
]}

Ancora, Massimo ^{[2
]}

Mangone, Iolanda ^{[2
]}

Di Pasquale, Adriano ^{[2
]}

Luppi, Andrea ^{[3
]}

Vio, Denis ^{[4
]}

Camma, Cesare ^{[2
]}

Magistrali, Chiara Francesca ^{[1
]}

机构：

[1] Ist Zooprofilatt Sperimentale Umbria & Marche Tog, Via Salvemini 1, I-06126 Perugia, Italy

[2] Ist Zooprofilatt Sperimentale Abruzzo & Molise Gi, Teramo, Italy

[3] Ist Zooprofilatt Sperimentale Lombardia & Emilia, Brescia, Italy

[4] Ist Zooprofilatt Sperimentale Venezie, Padua, Italy

来源：

EMERGING INFECTIOUS DISEASES | 2022年 / 28卷 / 01期

关键词：

VIRULENCE; PROTEIN; TOOL;

D O I：

10.3201/eid2801.210816

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus suis is a pathogen associated with severe diseases in pigs and humans. Human infections have a zoonotic origin in pigs. To assess circulating strains, we characterized the serotypes, sequence types, and antimicrobial susceptibility of 78 S. suis isolates from diseased farmed pigs in Italy during 2017-2019. Almost 60% of infections were caused by serotypes 1/2 and 9. All but 1 of the serotype 2 and 1/2 isolates were confined to a single cluster, and serotype 9 isolates were distributed along the phylogenetic tree. Besides sequence type (ST) 1, the serotype 2 cluster included ST7, which caused severe human infections in China in 1998 and 2005. A large proportion of serotype 9 isolates, assigned to ST123, were resistant to penicillin. The emergence of this clone threatens the successful treatment of S. suis infection. Characterizing S. suis isolates from pigs will promote earlier detection of emerging clones.

引用

页码：139 / 147

页数：9

共 48 条

[1] SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing [J].

Bankevich, Anton ;

Nurk, Sergey ;

Antipov, Dmitry ;

Gurevich, Alexey A. ;

Dvorkin, Mikhail ;

Kulikov, Alexander S. ;

Lesin, Valery M. ;

Nikolenko, Sergey I. ;

Son Pham ;

Prjibelski, Andrey D. ;

Pyshkin, Alexey V. ;

Sirotkin, Alexander V. ;

Vyahhi, Nikolay ;

Tesler, Glenn ;

Alekseyev, Max A. ;

Pevzner, Pavel A. .

JOURNAL OF COMPUTATIONAL BIOLOGY, 2012, 19 (05) :455-477

[2] Genetic and virulence-phenotype characterization of serotypes 2 and 9 of Streptococcus suis swine isolates [J].

Blume, Verena ;

Luque, Inmaculada ;

Vela, Ana I. ;

Borge, Carmen ;

Maldonado, Alfonso ;

Dominguez, Lucas ;

Tarradas, Carmen ;

Fernandez-Garayzabal, Jose F. .

INTERNATIONAL MICROBIOLOGY, 2009, 12 (03) :161-166

[3] Trimmomatic: a flexible trimmer for Illumina sequence data [J].

Bolger, Anthony M. ;

Lohse, Marc ;

Usadel, Bjoern .

BIOINFORMATICS, 2014, 30 (15) :2114-2120

[4] BLAST plus : architecture and applications [J].

Camacho, Christiam ;

Coulouris, George ;

Avagyan, Vahram ;

Ma, Ning ;

Papadopoulos, Jason ;

Bealer, Kevin ;

Madden, Thomas L. .

BMC BIOINFORMATICS, 2009, 10

[5] Minimum Core Genome Sequence Typing of Bacterial Pathogens: a Unified Approach for Clinical and Public Health Microbiology [J].

Chen, Chen ;

Zhang, Wen ;

Zheng, Han ;

Lan, Ruiting ;

Wang, Haiyin ;

Du, Pengcheng ;

Bai, Xuemei ;

Ji, Shaobo ;

Meng, Qiong ;

Jin, Dong ;

Liu, Kai ;

Jing, Huaiqi ;

Ye, Changyun ;

Gao, George F. ;

Wang, Lei ;

Gottschalk, Marcelo ;

Xu, Jianguo .

JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (08) :2582-2591

[6]

Clinical and Laboratory Standards Institute, 2018, VET08 PERF STAND ANT, V4th

[7]

Clinical and Laboratory Standards Institute, 2017, PERFORMANCE STANDARD, P27

[8] Multilocus sequence typing and virulence genotyping of Streptococcus suis serotype 9 isolates revealed high genetic and virulence diversity [J].

Dong, Wenyang ;

Zhu, Yinchu ;

Ma, Ye ;

Ma, Jiale ;

Zhang, Yue ;

Yuan, Lvfeng ;

Pan, Zihao ;

Wu, Zongfu ;

Yao, Huochun .

FEMS MICROBIOLOGY LETTERS, 2017, 364 (22)

[9] Virulence genotyping and population analysis of Streptococcus suis serotype 2 isolates from China [J].

Dong, Wenyang ;

Ma, Jiale ;

Zhu, Yinchu ;

Zhu, Jielian ;

Yuan, Lvfeng ;

Wang, Yanan ;

Xu, Jueqiong ;

Pan, Zihao ;

Wu, Zongfu ;

Zhang, Wei ;

Lu, Chengping ;

Yao, Huochun .

INFECTION GENETICS AND EVOLUTION, 2015, 36 :483-489

[10] The global emergence of a novel Streptococcus suis clade associated with human infections [J].

Dong, Xingxing ;

Chao, Yanjie ;

Zhou, Yang ;

Zhou, Rui ;

Zhang, Wei ;

Fischetti, Vincent A. ;

Wang, Xiaohong ;

Feng, Ye ;

Li, Jinquan .

EMBO MOLECULAR MEDICINE, 2021, 13 (07)

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