Long-term effects of pergolide in the treatment of restless legs syndrome

被引：78
|
作者：
Stiasny, K
Wetter, TC
Winkelmann, J
Brandenburg, U
Penzel, T
Rubin, M
Hundemer, HP
Oertel, WH
Trenkwalder, C
机构：
[1] Univ Marburg, Dept Neurol, Ctr Nervous Dis, D-35033 Marburg, Germany
[2] Univ Marburg, Dept Internal Med, Marburg, Germany
[3] Lilly Deutschland GMBH, Bad Homburg, Germany
来源：
NEUROLOGY | 2001年 / 56卷 / 10期
关键词：
D O I：
10.1212/WNL.56.10.1399
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.
引用
收藏
页码：1399 / 1402
页数：4
相关论文
共 50 条
  • [1] Long-term effect of pergolide in the treatment of restless legs syndrome
    Stiasny, K
    Wetter, TC
    Winkelmann, J
    Brandenburg, U
    Penzel, T
    Rubin, M
    Oertel, WH
    Trenkwalder, C
    NEUROLOGY, 2000, 54 (07) : A19 - A19
  • [2] Long-term effects of pramipexole in the treatment of restless legs syndrome
    Fantini, M
    Desautels, A
    Michaud, M
    Petit, D
    Montplaisir, J
    MOVEMENT DISORDERS, 2004, 19 : S428 - S428
  • [3] The safety of pergolide in the treatment of restless legs syndrome RLS: Results of a randomized long-term multicenter trial of pergolide in the treatment of RLS
    Hundemer, H
    Trenkwalder, C
    Lledo, A
    Quail, D
    Rubin, M
    Swieca, J
    Polo, O
    Wetter, T
    Strambi, L
    deGroen, J
    SLEEP, 2001, 24 : A17 - A17
  • [4] The safety of pergolide in the treatment of restless legs syndrome (RLS): Results of a randomized long-term multicenter trial of pergolide in the treatment of RLS
    Hundemer, HP
    Trenkwalder, C
    Lledo, A
    Quail, D
    Rubin, M
    Swieca, J
    Polo, O
    Wetter, TC
    Strambi, LF
    deGroen, HJ
    NEUROLOGY, 2001, 56 (08) : A20 - A20
  • [5] Treatment of the restless legs syndrome with pergolide
    Trenkwalder, C
    Winkelmann, J
    Stiasny, K
    Wetter, TC
    Oertel, WH
    NEUROLOGY, 1997, 48 (03) : 54005 - 54005
  • [6] Long-term treatment with pramipexole in restless legs syndrome
    Montplaisir, J.
    Fantini, M. L.
    Desautels, A.
    Michaud, M.
    Petit, D.
    Filipini, D.
    EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (12) : 1306 - 1311
  • [7] Augmentation of restless legs syndrome with long-term tramadol treatment
    Vetrugno, Roberto
    La Morgia, Chiara
    D'Angelo, Roberto
    Loi, Daniela
    Provini, Federica
    Plazzi, Giuseppe
    Montagna, Pasquale
    MOVEMENT DISORDERS, 2007, 22 (03) : 424 - 427
  • [8] Long-term treatment of restless legs syndrome with dopamine agonists
    Ondo, W
    Romanyshyn, J
    Vuong, KD
    Lai, DJ
    ARCHIVES OF NEUROLOGY, 2004, 61 (09) : 1393 - 1397
  • [9] Restless legs syndrome: clinical experience with long-term treatment
    Clavadetscher, SC
    Gugger, M
    Bassetti, CL
    SLEEP MEDICINE, 2004, 5 (05) : 495 - 500
  • [10] Restless legs syndrome: Clinical experience with long-term treatment
    Clavadetscher, SC
    Gugger, M
    Mathis, J
    Bassetti, CL
    SLEEP, 2001, 24 : A357 - A358
12345