Long-term effects of pergolide in the treatment of restless legs syndrome

被引：78
作者：
Stiasny, K
Wetter, TC
Winkelmann, J
Brandenburg, U
Penzel, T
Rubin, M
Hundemer, HP
Oertel, WH
Trenkwalder, C
机构：
[1] Univ Marburg, Dept Neurol, Ctr Nervous Dis, D-35033 Marburg, Germany
[2] Univ Marburg, Dept Internal Med, Marburg, Germany
[3] Lilly Deutschland GMBH, Bad Homburg, Germany
来源：
NEUROLOGY | 2001年 / 56卷 / 10期
关键词：
D O I：
10.1212/WNL.56.10.1399
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.
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收藏
页码：1399 / 1402
页数：4
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