Lymphoproliferative disease and cancer among patients with common variable immunodeficiency

被引：57

作者：

Gangemi, S. ^{[1
,2
]}

Allegra, A. ^{[3
]}

Musolino, C. ^{[3
]}

机构：

[1] Univ Hosp G Martino, Dept Clin & Expt Med, Sch & Div Allergy & Clin Immunol, Messina, Italy

[2] CNR, Messina Unit, Inst Clin Pathol, IFC, Messina, Italy

[3] Univ Messina, Div Hematol, Dept Gen Surg & Oncol, Messina, Italy

来源：

LEUKEMIA RESEARCH | 2015年 / 39卷 / 04期

关键词：

Common variable immunodeficiency; Lymphoma; Gastric cancer; Immune dysregulation; Innate immune deficiency; ANTIBODY-DEFICIENCY SYNDROME; IMMUNE-DEFICIENCY; COPY NUMBER; CLINICAL-MANIFESTATIONS; IMMUNOLOGICAL FEATURES; HODGKIN-LYMPHOMA; IGA DEFICIENCY; B-CELLS; DISORDERS; MUTATIONS;

D O I：

10.1016/j.leukres.2015.02.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Innate immune deficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. This review discusses the latest insights into the links between common variable immunodeficiency (CVI) and malignancies. Although Ig therapy greatly reduces the number of infections and enhances survival, it does not appear to address the development of cancer, especially lymphoma. The reasons for the increased susceptibility to lymphoid malignancies are unclear. These include genetics, immune dysregulation, radiosensitivity and chronic infections such as Helicobacter pylori, EBV, human herpes virus type 8 and cytomegalovirus. Further studies will allow us to better stratify the risk for cancer in these patients, and teach us to better prevent these complications and to better treat them. (C) 2015 The Authors. Published by Elsevier Ltd.

引用

页码：389 / 396

页数：8

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