Nickel-Catalyzed Decarbonylative Borylation and Silylation of Esters

被引：174

作者：

Pu, Xinghui ^{[1
]}

Hu, Jiefeng ^{[1
]}

Zhao, Yue ^{[1
]}

Shi, Zhuangzhi ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Chem Life Sci, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

ACS CATALYSIS | 2016年 / 6卷 / 10期

关键词：

nickel; borylation; silylation; esters; decarbonylation; C-H BONDS; CROSS-COUPLING REACTIONS; CARBON-CYANO BONDS; O BOND; DIRECTING GROUP; ARYL CHLORIDES; ORGANOBORON COMPOUNDS; REDUCTIVE CLEAVAGE; GRIGNARD-REAGENTS; DIRECT ALKYLATION;

D O I：

10.1021/acscatal.6b01956

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The nickel-catalyzed direct borylation and silylation of phenolic esters has been established. The key to this highly efficient acyl C-O bond borylative and silylative cleavage depends on the appropriate choice of different ligands and additives in the presence of nickel catalyst. Both transformations exhibit good functional group compatibility and can serve as powerful synthetic tools for late-stage functionalization of complex compounds. The elucidation of key mechanistic features of this newly developed acyl C-O bond activation in esters was confirmed by two well-characterized organonickel(II) intermediates.

引用

页码：6692 / 6698

页数：7

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