FORMULATION AND EVALUATION OF NEOMYCIN SULFATE HYDROGELS FOR WOUND HEALING

被引：0

作者：

Chauhan, Shikha Baghel ^{[1
]}

Gandla, Kumaraswamy ^{[2
]}

Kumar, Gudas Ganesh ^{[3
]}

Parveen, M. D. ^{[4
]}

Parija, Swalin ^{[5
]}

机构：

[1] Amity Univ, Amity Inst Pharm, Dept Pharmaceut, Noida 201313, Uttar Pradesh, India

[2] Chaitanya Deemed Univ, Dept Pharm, Hanumakonda 506001, Telangana, India

[3] Srikrupa Inst Pharmaceut Sci, Siddipet 502277, Telangana, India

[4] Max Inst Pharmaceut Sci, Khammam 507318, Telangana, India

[5] Inst Pharm & Technol, Cuttack 754202, Odisha, India

来源：

JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS | 2022年 / 13卷

关键词：

Hydrogels; Neomycin Sulphate; Wound Healing; MACROPHAGES;

D O I：

10.47750/pnr.2022.13.S01.30

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: The present study was designed to study the Neomycin Sulfate (NS)-loaded hydrogels to heal wounds. Material and Method: NS-loaded hydrogels were prepared by simple stirring method. Results: The prepared formulation exhibited good consistency, homogeneity and gelling strength. The application of gel on healthy volunteers revealed gels to be safe for skin. It also exhibited pH between 7.4-8.0 and drug content between 100 +/- 4% evaluated through microbial assay. In-vitro drug release data showed a fast initial drug release during the first 1 h, followed by a slower and sustained release over 5 h. Conclusion: The finding suggests that NS based hydrogel is suitable for drug delivery through topical application to enhance the dermal contact time and improved patient compliance.

引用

页码：234 / 253

页数：20