Palladium-Catalyzed Denitrogenative Carbonylation of Benzotriazoles with Cr(CO)6 as the Carbonyl Source

被引：14

作者：

An, Tongshun ^{[1
]}

Liu, Chenwei ^{[1
]}

Yin, Yanzhao ^{[1
]}

Wu, Xiao-Feng ^{[2
,3
]}

Yin, Zhiping ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China

[3] Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ORGANOMETALLICS | 2022年 / 41卷 / 13期

关键词：

OXIDATIVE CARBONYLATION; LIPASE INHIBITOR; ARYL IODIDES; HETEROCYCLES; MONOXIDE; AMINOCARBONYLATION; FUNCTIONALIZATIONS; CONSTRUCTION; CO-2(CO)(8); ACTIVATION;

D O I：

10.1021/acs.organomet.2c00243

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A general palladium and silver co-catalyzed denitrogenative carbonylation of benzotriazoles for the synthesis of benzoxazin-4-ones has been developed. Employing benzotriazoles as easily accessible substrates and Cr(CO)(6) as bench-stable solid carbonyl sources, various benzoxazin-4-ones were synthesized through a ring-opening/denitrogenative/carbonylation cascade processes in moderate to good yields. Notably, this protocol avoids the use of toxic CO gas and special equipment and can also be applied to the late-stage functionalization of substrates derived from the uricosuric agent probenecid.

引用

页码：1731 / 1737

页数：7

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