Unexpected fractionation in site-specific 13C isotopic distribution detected by quantitative 13C NMR at natural abundance

被引：39

作者：

Botosoa, Eliot P. ^{[1
]}

Caytan, Elsa ^{[1
]}

Silvestre, Virginie ^{[1
]}

Robins, Richard J. ^{[1
]}

Akoka, Serge ^{[1
]}

Remaud, Gerald S. ^{[1
]}

机构：

[1] Univ Nantes, CNRS, UMR 6006, Fac Sci & Technol,LAIEM, F-44322 Nantes 3, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 02期

关键词：

D O I：

10.1021/ja0771181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The recent development of C-13 NMR to measure absolute C-13/C-12 ratios at natural abundance has made it possible to examine.site-by-site variation at natural abundance. This technique has been applied to We common physical processes distillation and column chromatography. It is shown that the target molecules ethanol and vanillin respectively, bath show isotopic fractionation that differs in size and/or in sense at each carbon atom. The observation of this disparity in behavior is novel and unexpected. C-13 SNIF-NMR appears as a new effective tool to study noncovalent isotope effects (NCIE) an target molecules.

引用

页码：414 / +

页数：3

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