Functional Amyloids in Reproduction

被引：40

作者：

Hewetson, Aveline ^{[1
]}

Do, Hoa Quynh ^{[1
]}

Myers, Caitlyn ^{[1
]}

Muthusubramanian, Archana ^{[1
]}

Sutton, Roger Bryan ^{[2
]}

Wylie, Benjamin J. ^{[3
]}

Cornwall, Gail A. ^{[1
]}

机构：

[1] Texas Tech Univ Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA

[2] Texas Tech Univ Hlth Sci Ctr, Dept Cell Physiol & Mol Biophys, Lubbock, TX 79430 USA

[3] Texas Tech Univ, Dept Chem, Lubbock, TX 79409 USA

来源：

BIOMOLECULES | 2017年 / 7卷 / 03期

关键词：

amyloid; reproduction; spermatogenesis; fertilization; epididymis; zona pellucida; semen; cystatins; germline specification; HUMAN CYSTATIN-C; SEMEN-DERIVED ENHANCER; ZONA-PELLUCIDA; BINDING-PROTEINS; STRUCTURAL-CHARACTERIZATION; MOUSE SPERM; GERM PLASM; DOMAIN; MATRIX; FIBRILS;

D O I：

10.3390/biom7030046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloids are traditionally considered pathological protein aggregates that play causative roles in neurodegenerative disease, diabetes and prionopathies. However, increasing evidence indicates that in many biological systems nonpathological amyloids are formed for functional purposes. In this review, we will specifically describe amyloids that carry out biological roles in sexual reproduction including the processes of gametogenesis, germline specification, sperm maturation and fertilization. Several of these functional amyloids are evolutionarily conserved across several taxa, including human, emphasizing the critical role amyloids perform in reproduction. Evidence will also be presented suggesting that, if altered, some functional amyloids may become pathological.

引用

页数：15

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