Therapeutic effects of fibroblast growth factor-10 on hyperoxia-induced bronchopulmonary dysplasia in neonatal mice

被引:2
|
作者
Han, Tao [1 ,2 ]
Chi, Ming [1 ,2 ]
Wang, Yan [1 ]
Mei, Yabo [1 ]
Li, Qiuping [1 ]
Yu, Mengnan [1 ]
Ma, Qianqian [1 ]
Chen, Yuhan [1 ]
Feng, Zhichun [1 ]
机构
[1] PLA Army Gen Hosp, Bayi Childrens Hosp, Dept Pediat, Beijing, Peoples R China
[2] Second Mil Med Univ, Peoples Liberat Army, PLA Army, Clin Med Coll, Shanghai, Peoples R China
来源
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2017年 / 9卷 / 08期
关键词
fibroblast growth factor-10; hyperoxia; bronchopulmonary dysplasia; INDUCED LUNG INJURY; NF-KAPPA-B; MESENCHYMAL STEM-CELLS; BRANCHING MORPHOGENESIS; RESPIRATORY HEALTH; BUD MORPHOGENESIS; GLAND DEVELOPMENT; PRETERM BIRTH; FGF FAMILY; MOUSE LUNG;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The survival rate of preterm neonates increases significantly with the development of neonatal care and comprehensive treatment, but more and more high-risk preterm neonates suffer from bronchopulmonary dysplasia (BPD). Currently, there is no effective treatment for BPD, thus it is still a major cause of disability and mortality in neonates. Thus, it is imperative to investigate the pathogenesis and treatment of BPD in depth. Fibroblast growth factor-10 (FGF-10) is a paracrine growth factor binding its receptors (FGFR1 and FGFR2) to regulate a lot of biological processes. FGF-10, with mitotic and chemotactic activities, plays an important role in histogenesis during embryonic stage. It can prevent and attenuate mechanical or infection induced inflammation in lung. Results showed lung FGF-10 expression reduced significantly in neonatal mice with BPD, and exogenous FGF-10 was able to promote the growth of pulmonary mesenchymal stem cells and alveolar epithelial cells type II and reduce the expression of pro-inflammatory cytokines. We preliminarily explored the relationship between FGF-10 and NF-kappa B in this animal model and found FGF-10 could inhibit NF-kappa B p65 expression as a feedback. Thus, to investigate the protective effects of FGF-10 on hyperoxia induced BPD in neonatal mice will provide a new strategy for the treatment of BPD.
引用
收藏
页码:3528 / 3540
页数:13
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