Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus

被引：37
作者：
Tomita, M
Holman, BJ
Santoro, TJ
机构：
[1] Med Coll Ohio, Dept Med, Toledo, OH 43614 USA
[2] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA
来源：
NEUROSCIENCE LETTERS | 2001年 / 302卷 / 2-3期
关键词：
cytokines; hippocampus; systemic lupus erythematosus; MRL-lpr/lpr mice; gene expression;
D O I：
10.1016/S0304-3940(01)01679-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA, Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human acid experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus, (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：129 / 132
页数：4
相关论文
共 21 条
  • [11] Murray CA, 1998, J NEUROSCI, V18, P2974
  • [12] INTERLEUKIN-1-BETA, BUT NOT INTERLEUKIN-6, IMPAIRS SPATIAL NAVIGATION LEARNING
    OITZL, MS
    VANOERS, H
    SCHOBITZ, B
    DEKLOET, ER
    [J]. BRAIN RESEARCH, 1993, 613 (01) : 160 - 163
  • [13] NEURONAL DIFFERENTIATION FACTORS CYTOKINES AND SYNAPTIC PLASTICITY
    PATTERSON, PH
    NAWA, H
    [J]. CELL, 1993, 72 : 123 - 137
  • [14] CYTOKINE NETWORK IN THE CENTRAL-NERVOUS-SYSTEM AND ITS ROLES IN GROWTH AND DIFFERENTIATION OF GLIAL AND NEURONAL CELLS
    SAWADA, M
    SUZUMURA, A
    MARUNOUCHI, T
    [J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1995, 13 (3-4) : 253 - 264
  • [15] VERY SEVERE AMNESIA WITH ACUTE ONSET AFTER ISOLATED HIPPOCAMPAL DAMAGE DUE TO SYSTEMIC LUPUS-ERYTHEMATOSUS
    SCHNIDER, A
    BASSETTI, C
    GUTBROD, K
    OZDOBA, C
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1995, 59 (06) : 644 - 646
  • [16] THE BASIS OF AUTOIMMUNITY .1. MECHANISMS OF ABERRANT SELF-RECOGNITION
    THEOFILOPOULOS, AN
    [J]. IMMUNOLOGY TODAY, 1995, 16 (02): : 90 - 98
  • [17] TOMITA M, 2001, IN PRESS PHYTOTHER R
  • [18] EVALUATION OF MEMORY, LEARNING-ABILITY, AND CLINICAL NEUROLOGIC FUNCTION IN PATHOGEN-FREE MICE WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
    VOGELWEID, CM
    WRIGHT, DC
    JOHNSON, JC
    HEWETT, JE
    WALKER, SE
    [J]. ARTHRITIS AND RHEUMATISM, 1994, 37 (06): : 889 - 897
  • [19] Memory, learning ability, and neuropathologic status of mice with systemic lupus erythematosus
    Walker, SE
    Wright, DC
    OSullivan, FX
    Johnson, GC
    BeschWilliford, CL
    Vogelweid, CM
    [J]. NEUROPSYCHIATRIC MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS, 1997, 823 : 107 - 115
  • [20] WEST SG, 1994, RHEUM DIS CLIN N AM, V20, P129
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