The Delivery of mRNA Vaccines for Therapeutics

被引：46
作者：
Nitika [1 ,2 ]
Wei, Jiao [1 ,2 ]
Hui, Ai-Min [1 ,2 ]
机构：
[1] Fosun Pharma USA Inc, Boston, MA 02421 USA
[2] Shanghai Fosun Pharmaceut Ind Dev Co Ltd, Shanghai 200233, Peoples R China
来源：
LIFE-BASEL | 2022年 / 12卷 / 08期
关键词：
mRNA; vaccines; delivery route; formulations; delivery methods; immunity; RESPIRATORY SYNCYTIAL VIRUS; DENDRITIC CELL VACCINES; LIPID NANOPARTICLES; IMMUNE-RESPONSES; INFLUENZA-VIRUS; PROTECTIVE EFFICACY; CATIONIC LIPIDS; RABIES VACCINE; CANCER-THERAPY; IMMUNOGENICITY;
D O I：
10.3390/life12081254
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier play an important role. mRNA vaccines can be delivered using lipid nanoparticles, polymers, peptides or naked mRNA. The vaccine efficacy is influenced by the appropriate delivery materials, formulation methods and selection of a proper administration route. In addition, co-delivery of several mRNAs could also be beneficial and enhance immunity against various variants of an infectious pathogen or several pathogens altogether. Here, we review the recent progress in the delivery methods, modes of delivery and patentable mRNA vaccine technologies.
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页数：16
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