Intra-articular photodynamic therapy mechanisms for osteoarthritis treatment

被引：0
|
作者：
Makarov, V. I. [1 ]
Zharova, T. A. [2 ]
Kogan, E. A. [2 ]
Smorchkov, M. M. [3 ]
Lychagin, A. V. [2 ]
Ivannikov, S. V. [2 ]
Zharkov, N. V. [2 ]
Loschenov, V. B. [1 ]
机构：
[1] Russian Acad Sci, Prokhorov Gen Phys Inst, Moscow, Russia
[2] Sechenov Univ, IM Sechenov Moscow State Med Univ 1, Moscow, Russia
[3] NN Priorov Cent Res Inst Traumatol & Orthoped, Moscow, Russia
来源：
INTERNATIONAL CONFERENCE LASER OPTICS 2020 (ICLO 2020) | 2020年
关键词：
osteoarthritis; synovitis; macrophages; caspase-3; photosensitizer dose; chlorin e6; photodynamic therapy;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
This study focuses on investigation of intra-articular photodynamic therapy (PDT) mechanisms for osteoarthritis (OA) treatment. Also, a search for determination of the most effective dose of photosensitizer (PS) chlorine e6 (Ce6) for anti-inflammatory PDT of OA was carried out. It was found that to assess the PDT effectiveness in the treatment of OA accompanied by synovitis, it is sufficient to analyze for caspase-3 with the condition that the biopsy sample is taken 2-3 days after PDT. The results of the study on the efficacy of PDT with Photoditazin at various administered doses in the treatment of OA showed that 3.2 mg/kg PS dose (1 mg/kg for a human) is the most effective.
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