Signal transduction via platelet-derived growth factor receptors

被引：442

作者：

Heldin, CH ^{[1
]}

Östman, A ^{[1
]}

Rönnstrand, L ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Ctr Biomed, S-75124 Uppsala, Sweden

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 1998年 / 1378卷 / 01期

关键词：

platelet-derived growth factor; receptor; kinase; signal transduction; cell growth; cell migration; cell transformation; antagonist;

D O I：

10.1016/S0304-419X(98)00015-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules. Thereby, a number of different signaling pathways are initiated leading to cell growth, actin reorganization migration and differentiation. Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：F79 / F113

页数：35

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