Investigation of Osteoblast-like MC3T3-E1 Cells on a Collagen-like Protein and Poly (lactic-co-glycolic acid) Nanofibrous Composite Scaffold

被引：0

作者：

Li, Yuan ^{[1
]}

Teramoto, A. ^{[1
]}

Abe, K. ^{[1
]}

机构：

[1] Shinshu Univ, Dept Funct Polymer Sci, Fac Text Sci & Technol, Nagano, Japan

来源：

PROCEEDINGS OF THE SECOND INTERNATIONAL CONFERENCE ON ADVANCED TEXTILE MATERIALS & MANUFACTURING TECHNOLOGY | 2010年

关键词：

Nanofibrous Composite; Electrospun composite fibers; Collagen-like protein; ELECTROSPUN; EMULSION;

D O I：

暂无

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

We present an effective emulsion eletrospinning method in obtaining collagen-like protein (denoted as Fol-8Col) and poly(lactic-co-glycolic acid) (PLGA) nanofibrous composite scaffolds. The reservation of Fol-8Col's chemical structure has been confirmed by FT-IR spectra on electrospun composite fibers. Importantly, compared to fibrous mat without Fol-8Col, the osteoblastic behavior on the nanofibrous composite scaffolds was enhanced. The novelty of the process was that Fol-8Col in the scaffold had a positive modulation on early osteoblast adhesion and extension (within 24 hours) compared to neat PLGA. We concluded that this effective emulsion electrospinning is able to fabricate novel Fol-8Col/PLGA nanofibrous composite scaffolds which is promising for bone tissue engineering application.

引用

页码：59 / 62

页数：4