The cardiovascular protective role of docosahexaenoic acid

被引：176

作者：

McLennan, P ^{[1
]}

Howe, P ^{[1
]}

Abeywardena, M ^{[1
]}

Muggli, R ^{[1
]}

Raederstorff, D ^{[1
]}

Mano, M ^{[1
]}

Rayner, T ^{[1
]}

Head, R ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE LTD, BASEL, SWITZERLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 300卷 / 1-2期

关键词：

dietary fat; n-3 fatty acid; arrhythmia; blood pressure; proteinuria; thromboxane;

D O I：

10.1016/0014-2999(95)00861-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dietary fish oils rich in n-3 polyunsaturated fatty acids can modulate a diverse range of factors contributing to cardiovascular disease. This study examined the relative roles of eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA) which are the principal n-3 polyunsaturated fatty acids regarded as candidates for cardioprotective actions. At low dietary intakes (0.4-1.1% of energy (%en)), docosahexaenoic acid but not eicosapentaenoic acid inhibited ischaemia-induced cardiac arrhythmias. At intakes of 3.9-10.0%en, docosahexaenoic acid was more effective than eicosapentaenoic acid at retarding hypertension development in spontaneously hypertensive rats (SHR) and inhibiting thromboxane-like vasoconstrictor responses in aortas from SHR. In stroke-prone SHR with established hypertension, docosahexaenoic acid (3.9-10.0%en) retarded the development of salt-loading induced proteinuria but eicosapentaenoic acid alone was ineffective. The results demonstrate that purified n-3 polyunsaturated fatty acids mimic the cardiovascular actions of fish oils and imply that docosahexaenoic acid may be the principal active component conferring cardiovascular protection.

引用

页码：83 / 89

页数：7

共 36 条

[1] DIFFERENTIAL-EFFECTS OF DIETARY FISH OIL ON MYOCARDIAL PROSTAGLANDIN-I2 AND THROMBOXANE-A2 PRODUCTION [J].