The promise of optogenetics in cell biology: interrogating molecular circuits in space and time

被引：76
作者：
Toettcher, Jared E. [1 ,2 ]
Voigt, Christopher A. [3 ]
Weiner, Orion D. [2 ]
Lim, Wendell A. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA
来源：
NATURE METHODS | 2011年 / 8卷 / 01期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
LIVING CELLS; PROTEIN; LOCALIZATION; CHANNELS; ALLELES;
D O I：
10.1038/NMETH.F.326
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Optogenetic modules offer cell biologists unprecedented new ways to poke and prod cells. The combination of these precision perturbative tools with observational tools, such as fluorescent proteins, may dramatically accelerate our ability to understand the inner workings of the cell.
引用
收藏
页码：35 / 38
页数：4
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