Adhesion molecules and matrix metalloproteinases in Multiple Sclerosis: effects induced by Interferon-beta

被引：29

作者：

Avolio, C ^{[1
]}

Giuliani, F

Liuzzi, GM

Ruggieri, M

Paolicelli, D

Riccio, P

Livrea, P

Trojano, M

机构：

[1] Univ Foggia, Neurol Unit, Foggia, Italy

[2] Univ Bari, Dept Neurol & Psychiat Sci, Bari, Italy

[3] Univ Bari, Dept Biochem & Mol Biol, Bari, Italy

[4] Univ Basilicata, DBAF, Dept Biol, I-85100 Potenza, Italy

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 61卷 / 03期

关键词：

Interferon-beta; adhesion molecules; matrix metalloproteinases; Multiple Sclerosis;

D O I：

10.1016/S0361-9230(03)00098-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Multiple Sclerosis (MS) pathology, early inflammation involves leukocyte migration across the blood-brain barrier (BBB) within the central nervous system. In this process, adhesion molecules (AMs), both membrane-bound and soluble-circulating forms, and matrix metalloproteinases (MMPs) certainly play a regulatory role. In MS, recombinant Interferon-beta (rIFNbeta) is effective in reducing gadolinium contrast-enhancing lesions on magnetic resonance imaging and this suggests that it may reduce BBB damage or even restore its integrity by different mechanisms that include interference with both AM and MMP pathways. This review will highlight the effects induced by rIFNbeta, both in vitro and in vivo, on cell-bound and soluble forms of AMs and on MMPs. (C) 2003 Elsevier Science Inc. All rights reserved.

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收藏

页码：357 / 364

页数：8

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