Symptomology following mRNA vaccination against SARS-CoV-2

被引：11

作者：

Ebinger, Joseph E. ^{[1
,2
]}

Lan, Roy ^{[3
]}

Sun, Nancy ^{[1
,2
]}

Wu, Min ^{[1
,2
]}

Joung, Sandy ^{[1
,2
]}

Botwin, Gregory J. ^{[4
]}

Botting, Patrick ^{[1
,2
]}

Al-Amili, Daniah ^{[5
]}

Aronow, Harriet ^{[6
]}

Beekley, James ^{[7
]}

Coleman, Bernice ^{[6
]}

Contreras, Sandra ^{[7
]}

Cozen, Wendy ^{[8
,9
,10
]}

Davis, Jennifer ^{[4
]}

Debbas, Philip ^{[4
]}

Diaz, Jacqueline ^{[1
,2
]}

Driver, Matthew ^{[1
,2
]}

Fert-Bober, Justyna ^{[1
,2
,11
]}

Gu, Quanquan ^{[12
]}

Heath, Mallory ^{[1
,2
]}

Herrera, Ergueen ^{[7
]}

Hoang, Amy ^{[1
,2
]}

Hussain, Shehnaz K. ^{[7
]}

Huynh, Carissa ^{[13
]}

Kim, Linda ^{[6
]}

Kittleson, Michelle ^{[1
,2
]}

Liu, Yunxian ^{[1
,2
]}

Lloyd, John ^{[1
,2
]}

Luong, Eric ^{[1
,2
]}

Malladi, Bhavya ^{[1
,2
]}

Merchant, Akil ^{[14
]}

Merin, Noah ^{[15
]}

Mujukian, Angela ^{[4
]}

Nguyen, Nathalie ^{[7
]}

Nguyen, Trevor-Trung ^{[1
,2
]}

Pozdnyakova, Valeriya ^{[4
]}

Rashid, Mohamad ^{[1
,2
]}

Raedschelders, Koen ^{[11
]}

Reckamp, Karen L. ^{[7
]}

Rhoades, Kylie ^{[1
,2
]}

Sternbach, Sarah ^{[1
,2
]}

Vallejo, Rocio ^{[1
,2
]}

White, Shane ^{[4
]}

Tompkins, Rose ^{[1
,2
]}

Wong, Melissa ^{[16
]}

Arditi, Moshe ^{[2
,17
,18
,22
]}

Figueiredo, Jane C. ^{[7
]}

Van Eyk, Jennifer E. ^{[1
,2
,11
]}

Miles, Peggy B. ^{[19
]}

Chavira, Cynthia ^{[14
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Cardiol, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Smidt Heart Inst, Los Angeles, CA 90048 USA

[3] Univ Tennessee, Ctr Hlth Sci, Coll Med, Memphis, TN 38163 USA

[4] Cedars Sinai, F Widjaja Fdn Inflammatory Bowel & Immunobiol Res, Los Angeles, CA USA

[5] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA

[6] Cedars Sinai Med Ctr, Brawerman Nursing Inst, Los Angeles, CA 90048 USA

[7] Cedars Sinai Med Ctr, Dept Med, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[8] UCI, Dept Med, Div Hematol Oncol, Sch Med, Irvine, CA USA

[9] UCI, Dept Pathol, Sch Med, Irvine, CA USA

[10] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA USA

[11] Cedars Sinai Med Ctr, Adv Clin Biosyst Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA

[12] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90024 USA

[13] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Biobank & Translat Res Core Lab, Los Angeles, CA 90048 USA

[14] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

[15] Cedars Sinai Med Ctr, Dept Internal Med, Div Hematol, Los Angeles, CA 90048 USA

[16] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Maternal Fetal Med, Los Angeles, CA 90048 USA

[17] Dept Pediat, Div Infect Dis, Los Angeles, CA USA

[18] Immunol & Infect Immunol Dis Res Ctr IIDRC, Los Angeles, CA USA

[19] Cedars Sinai Med Ctr, Dept Med, Employee Hlth Serv, Los Angeles, CA 90048 USA

[20] Cedar Sinai Med Ctr, Dept Pharm, Los Angeles, CA USA

[21] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[22] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA

来源：

PREVENTIVE MEDICINE | 2021年 / 153卷

关键词：

SARS-CoV-2; Vaccination; Vaccine-associated symptoms; PRACTICES INTERIM RECOMMENDATION; UNITED-STATES; ADVISORY-COMMITTEE; COVID-19; VACCINE;

D O I：

10.1016/j.ypmed.2021.106860

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Despite demonstrated efficacy of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), the causative agent of coronavirus disease-2019 (COVID-19), widespread hesitancy to vaccination persists. Improved knowledge regarding frequency, severity, and duration of vaccine-associated symptoms may help reduce hesitancy. In this prospective observational study, we studied 1032 healthcare workers who received both doses of the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine and completed post-vaccine symptom surveys both after dose 1 and after dose 2. We defined appreciable post-vaccine symptoms as those of at least moderate severity and lasting at least 2 days. We found that symptoms were more frequent following the second vaccine dose than the first (74% vs. 60%, P 0.001), with 80% of all symptoms resolving within 2 days. The most common symptom was injection site pain, followed by fatigue and malaise. Overall, 20% of participants experienced appreciable symptoms after dose 1 and 30% after dose 2. In multivariable analyses, female sex was associated with greater odds of appreciable symptoms after both dose 1 (OR, 95% CI 1.73, 1.19-2.51) and dose 2 (1.76, 1.28-2.42). Prior COVID-19 was also associated with appreciable symptoms following dose 1, while younger age and history of hypertension were associated with appreciable symptoms after dose 2. We conclude that most post-vaccine symptoms are reportedly mild and last <2 days. Appreciable post-vaccine symptoms are associated with female sex, prior COVID-19, younger age, and hypertension. This information can aid clinicians in advising patients on the safety and expected symptomatology associated with vaccination.

引用

页数：8

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