Cancer stem cell metabolism

被引：350
作者：
Peiris-Pages, Maria [1 ,2 ]
Martinez-Outschoorn, Ubaldo E. [3 ]
Pestell, Richard G. [3 ]
Sotgia, Federica [1 ,2 ]
Lisanti, Michael P. [1 ,2 ]
机构：
[1] Univ Manchester, CRUK Manchester Inst, Inst Canc Sci, Breast Canc Now Res Unit, Paterson Bldg, Manchester, Lancs, England
[2] Univ Manchester, CRUK Manchester Inst, Inst Canc Sci, MCCM, Paterson Bldg, Manchester, Lancs, England
[3] Sidney Kimmel Canc Ctr, Philadelphia, PA USA
来源：
BREAST CANCER RESEARCH | 2016年 / 18卷
基金：
美国国家卫生研究院;
关键词：
BREAST-CANCER; OXIDATIVE-PHOSPHORYLATION; QUANTITATIVE PROTEOMICS; MITOCHONDRIAL MASS; ENERGY-METABOLISM; TUMOR-GROWTH; METASTASIS; RESISTANCE; PATHWAY; FIBROBLASTS;
D O I：
10.1186/s13058-016-0712-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.
引用
收藏
页数：10
相关论文
共 96 条
[1]   Cells, Stem Cells, and Cancer Stem Cells [J].
Aguilar-Gallardo, Cristobal ;
Simon, Carlos .
SEMINARS IN REPRODUCTIVE MEDICINE, 2013, 31 (01) :5-13
[2]   Tumor Macroenvironment and Metabolism [J].
Al-Zhoughbi, Wael ;
Huang, Jianfeng ;
Paramasivan, Ganapathy S. ;
Till, Holger ;
Pichler, Martin ;
Guertl-Lackner, Barbara ;
Hoefler, Gerald .
SEMINARS IN ONCOLOGY, 2014, 41 (02) :281-295
[3]   Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells [J].
An, Hyunsook ;
Kim, Ji Young ;
Oh, Eunhye ;
Lee, Nahyun ;
Cho, Youngkwan ;
Seo, Jae Hong .
PLOS ONE, 2015, 10 (11)
[4]   EMT-induced metabolite signature identifies poor clinical outcome [J].
Bhowmik, Salil Kumar ;
Ramirez-Pena, Esmeralda ;
Arnold, James Michael ;
Putluri, Vasanta ;
Sphyris, Nathalie ;
Michailidis, George ;
Putluri, Nagireddy ;
Ambs, Stefan ;
Sreekumar, Arun ;
Mani, Sendurai A. .
ONCOTARGET, 2015, 6 (40) :42651-42660
[5]   Mitochondrially targeted anti-cancer agents [J].
Biasutto, Lucia ;
Dong, Lan-Feng ;
Zoratti, Mario ;
Neuzil, Jiri .
MITOCHONDRION, 2010, 10 (06) :670-681
[6]   Ketones and lactate "fuel" tumor growth and metastasis Evidence that epithelial cancer cells use oxidative mitochondrial metabolism [J].
Bonuccelli, Gloria ;
Tsirigos, Aristotelis ;
Whitaker-Menezes, Diana ;
Pavlides, Stephanos ;
Pestell, Richard G. ;
Chiavarina, Barbara ;
Frank, Philippe G. ;
Flomenberg, Neal ;
Howell, Anthony ;
Martinez-Outschoorn, Ubaldo E. ;
Sotgia, Federica ;
Lisanti, Michael P. .
CELL CYCLE, 2010, 9 (17) :3506-3514
[7]   Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer [J].
Brooks, Michael D. ;
Burness, Monika L. ;
Wicha, Max S. .
CELL STEM CELL, 2015, 17 (03) :260-271
[8]   Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models [J].
Cheong, Jae-Ho ;
Park, Eun Sung ;
Liang, Jiyong ;
Dennison, Jennifer B. ;
Tsavachidou, Dimitra ;
Catherine Nguyen-Charles ;
Cheng, Kwai Wa ;
Hall, Hassan ;
Zhang, Dong ;
Lu, Yiling ;
Ravoori, Murali ;
Kundra, Vikas ;
Ajani, Jaffer ;
Lee, Ju-Seog ;
Hong, Waun Ki ;
Mills, Gordon B. .
MOLECULAR CANCER THERAPEUTICS, 2011, 10 (12) :2350-2362
[9]   Metabolic reprogramming and two-compartment tumor metabolism Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells [J].
Chiavarina, Barbara ;
Martinez-Outschoorn, Ubaldo E. ;
Whitaker-Menezes, Diana ;
Howell, Anthony ;
Tanowitz, Herbert B. ;
Pestell, Richard G. ;
Sotgia, Federica ;
Lisanti, Michael P. .
CELL CYCLE, 2012, 11 (17) :3280-3289
[10]   HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells Autophagy drives compartment-specific oncogenesis [J].
Chiavarina, Barbara ;
Whitaker-Menezes, Diana ;
Migneco, Gemma ;
Martinez-Outschoorn, Ubaldo E. ;
Pavlides, Stephanos ;
Howell, Anthony ;
Tanowitz, Herbert B. ;
Casimiro, Mathew C. ;
Wang, Chenguang ;
Pestell, Richard G. ;
Grieshaber, Philip ;
Caro, Jaime ;
Sotgia, Federica ;
Lisanti, Michael P. .
CELL CYCLE, 2010, 9 (17) :3534-3551
12345678910