Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus

被引：133

作者：

Kenny, PJ

File, SE

Rattray, M

机构：

[1] Univ London Kings Coll, GKT Sch Biomed Sci, Neurosci Res Ctr, Biochem Neuropharmacol Grp, London SE1 1UL, England

[2] Univ London Kings Coll, GKT Sch Biomed Sci, Neurosci Res Ctr, Psychopharmacol Res Unit, London SE1 1UL, England

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 85卷 / 1-2期

关键词：

neurotrophin; withdrawal; in situ hybridisation; acetylcholine; drug dependence;

D O I：

10.1016/S0169-328X(00)00246-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acute nicotine administration (0.5 mg/kg i.p.) significantly decreased BDNF mRNA levels in dentate gyrus, CA3 and CA1 subfields of the rat hippocampus 2 h and 24 h after administration. However, with 7 days nicotine treatment, tolerance developed to the inhibitory effect of nicotine on BDNF mRNA expression and there was a significant increase in BDNF expression 2 h after the final injection in the CA1 region. These data suggests that changes in expression of hippocampal BDNF may be involved in the behavioural effects of nicotine observed after acute and chronic treatment. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：234 / 238

页数：5

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