Long-term sleep disturbances in children: A cause of neuronal loss

被引:124
作者
Jan, James E. [1 ,3 ]
Reiter, Russ J. [4 ]
Bax, Martin C. O. [5 ]
Ribary, Urs [6 ]
Freeman, Roger D. [2 ,7 ]
Wasdell, Michael B. [8 ]
机构
[1] BC Childrens Hosp, Vancouver, BC V6H 3N1, Canada
[2] Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada
[3] Child & Family Res Inst, Vancouver, BC, Canada
[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA
[5] Univ London Imperial Coll Sci Technol & Med, London, England
[6] Simon Fraser Univ, Behav & Cognit Neurosci Inst, Burnaby, BC V5A 1S6, Canada
[7] BC Childrens Hosp, Neuropsychiat Clin, Vancouver, BC, Canada
[8] Fraser Hlth Author, Surrey, BC, Canada
关键词
Children; Sleep deprivation; Cellular stress; Intellectual loss; Melatonin; POSTTRAUMATIC-STRESS-DISORDER; EYE-MOVEMENT SLEEP; CEREBRAL-CORTEX; MELATONIN THERAPY; REM-SLEEP; IN-VITRO; FUNCTIONAL CONNECTIVITY; BASAL FOREBRAIN; REACTIVE OXYGEN; MEMORY DEFICITS;
D O I
10.1016/j.ejpn.2010.05.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Short-term sleep loss is known to cause temporary difficulties in cognition, behaviour and health but the effects of persistent sleep deprivation on brain development have received little or no attention. Yet, severe sleep disorders that last for years are common in children especially when they have neurodevelopmental disabilities. There is increasing evidence that chronic sleep loss can lead to neuronal and cognitive loss in children although this is generally unrecognized by the medical profession and the public. Without the restorative functions of sleep due to total sleep deprivation, death is inevitable within a few weeks. Chronic sleep disturbances at any age deprive children of healthy environmental exposure which is a prerequisite for cognitive growth more so during critical developmental periods. Sleep loss adversely effects pineal melatonin production which causes disturbance of circadian physiology of cells, organs, neurochemicals, neuroprotective and other metabolic functions. Through various mechanisms sleep loss causes widespread deterioration of neuronal functions, memory and learning, gene expression, neurogenesis and numerous other changes which cause decline in cognition, behaviour and health. When these changes are long-standing, excessive cellular stress develops which may result in widespread neuronal loss. In this review, for the first time, recent research advances obtained from various fields of sleep medicine are integrated in order to show that untreated chronic sleep disorders may lead to impaired brain development, neuronal damage and permanent loss of developmental potentials. Further research is urgently needed because these findings have major implications for the treatment of sleep disorders. (C) 2010 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:380 / 390
页数:11
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