Mechanisms of Disease of Eosinophilic Esophagitis

被引：62
作者：
Davis, Benjamin P. [1 ]
Rothenberg, Marc E. [2 ]
机构：
[1] Univ Iowa Hosp & Clin, Div Immunol, Dept Internal Med, Iowa City, IA 52242 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol, Cincinnati, OH 45229 USA
来源：
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 | 2016年 / 11卷
关键词：
eosinophilic esophagitis; atopy; barrier dysfunction; epithelial inflammation; fibrosis; THYMIC STROMAL LYMPHOPOIETIN; EPITHELIAL-MESENCHYMAL TRANSITION; EOTAXIN-3/CCL26; GENE-EXPRESSION; DENDRITIC CELLS; ADULT PATIENTS; ALLERGIC LUNG; FOOD ALLERGY; TRANSCRIPTOME ANALYSIS; ANTIGEN PRESENTATION; CYTOKINE EXPRESSION;
D O I：
10.1146/annurev-pathol-012615-044241
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.
引用
收藏
页码：365 / 393
页数：29
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