8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation

被引：149

作者：

Groll, Andreas H. ^{[1
,2
]}

Pana, Dorothea ^{[3
]}

Lanternier, Fanny ^{[4
]}

Mesini, Alessio ^{[5
]}

Ammann, Roland A. ^{[6
]}

Averbuch, Dina ^{[7
]}

Castagnola, Elio ^{[5
]}

Cesaro, Simone ^{[8
]}

Engelhard, Dan ^{[7
]}

Garcia-Vidal, Carolina ^{[9
,10
]}

Kanerva, Jukka ^{[11
,12
]}

Ritz, Nicole ^{[13
]}

Roilides, Emmanuel ^{[14
,15
]}

Stycynski, Jan ^{[16
]}

Warris, Adilia ^{[17
,18
]}

Lehrnbecher, Thomas ^{[19
]}

机构：

[1] Univ Childrens Hosp Munster, Ctr Bone Marrow Transplantat, Infect Dis Res Program, D-48149 Munster, Germany

[2] Univ Childrens Hosp Munster, Dept Pediat Hematol & Oncol, D-48149 Munster, Germany

[3] European Univ Cyprus, Dept Med, Nicosia, Cyprus

[4] Univ Paris, Assistance Publ Hop Paris, Infect Dis Unit, Necker Enfants Malad, Paris, France

[5] IRCCS Ist Giannina Gaslini, Infect Dis Unit, Dept Pediat, Genoa, Italy

[6] Bern Univ Hosp, Pediat Hematol & Oncol, Dept Pediat, Bern, Switzerland

[7] Hebrew Univ Med Ctr, Dept Pediat, Jerusalem, Israel

[8] Azienda Osped Univ Integrata, Pediat Hematol Oncol, Dept Mother & Child, Verona, Italy

[9] Univ Barcelona, Dept Infect Dis, Hosp Clin Barcelona, Barcelona, Spain

[10] Univ Barcelona, IDIBAPS, Barcelona, Spain

[11] Univ Helsinki, Div Hematol Oncol & Stem Cell Transplantat, New Childrens Hosp, Helsinki, Finland

[12] Helsinki Univ Hosp, Helsinki, Finland

[13] Univ Basel, Childrens Hosp, Pediat Infect Dis & Vaccinol, Basel, Switzerland

[14] Aristotle Univ Thessaloniki, Infect Dis Unit, Dept Pediat 3, Fac Hlth Sci, Thessaloniki, Greece

[15] Aristotle Univ Thessaloniki, Hippokrat Hosp, Thessaloniki, Greece

[16] Nicolaus Copernicus Univ Torun, Dept Pediat Hematol & Oncol, Coll Med, Bydgoszcz, Poland

[17] Univ Exeter, MRC Ctr Med Mycol, Exeter, Devon, England

[18] Great Ormond St Hosp London, London, England

[19] Goethe Univ Frankfurt, Hosp Children & Adolescents, Pediat Hematol & Oncol, Frankfurt, Germany

来源：

LANCET ONCOLOGY | 2021年 / 22卷 / 06期

关键词：

LIPOSOMAL AMPHOTERICIN-B; EMPIRICAL ANTIFUNGAL THERAPY; BETA-D-GLUCAN; ITRACONAZOLE ORAL SOLUTION; NEUTROPENIC PATIENTS; DOUBLE-BLIND; PULMONARY ASPERGILLOSIS; FLUCONAZOLE PROPHYLAXIS; PERSISTENT FEVER; BONE-MARROW;

D O I：

10.1016/S1470-2045(20)30723-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Paediatric patients with cancer and those undergoing allogeneic haematopoietic cell transplantation have an increased susceptibility to invasive fungal diseases. In addition to differences in underlying conditions and comorbidities relative to adults, invasive fungal diseases in infants, children, and adolescents are unique in terms of their epidemiology, the validity of current diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of phase 3 clinical trials to provide data to guide evidence-based interventions. To reexamine the state of knowledge and to further improve invasive fungal disease diagnosis, prevention, and management, the 8th European Conference on Infections in Leukaemia (ECIL-8) reconvened a Paediatric Group to review the literature and to formulate updated recommendations according to the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and European Confederation of Medical Mycology (ECMM) grading system, which are summarised in this Review.

引用

页码：E254 / E269

页数：16

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