IgA-Mediated Autoimmune Hemolytic Anemia in an Infant

被引:9
作者
McGann, Patrick T. [1 ]
McDade, Jenny [1 ]
Mortier, Nicole A. [1 ]
Combs, Martha R. [2 ]
Ware, Russell E. [1 ]
机构
[1] St Jude Childrens Hosp, Dept Hematol, Memphis, TN 38105 USA
[2] Duke Univ, Med Ctr, Transfus Serv, Durham, NC USA
关键词
Autoimmune hemolytic anemia; Immunohematology; Erythrocytes; RED-CELL AUTOANTIBODIES; GEL; CHILDREN;
D O I
10.1002/pbc.22932
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Autoimmune hemolytic anemia (AIHA) is characterized by the presence of autoantibodies, most frequently of the IgG isotype, directed against erythrocyte surface antigens. The direct antiglobulin test (DAT) is the critical laboratory test for the diagnosis of AIHA, but is negative in 3-11% of cases. In these cases of DAT negative AIHA, a wider spectrum of clinical data including more specialized testing for erythrocyte autoantibodies may be required. We describe the unique and challenging case of an infant with corticosteroid-responsive, DAT negative AIHA, in which specialized gel card testing identified an isolated IgA autoantibody on the erythrocyte surface. Pediatr Blood Cancer 2011;56:837-839. (c) 2010 Wiley-Liss, Inc.
引用
收藏
页码:837 / 839
页数:3
相关论文
共 15 条
  • [1] Comparison of three microtube column agglutination systems for antibody screening:: DG Gel, DiaMed-ID and Ortho BioVue
    Cid, J
    Nogués, N
    Montero, R
    Hurtado, M
    Briega, A
    Parra, R
    [J]. TRANSFUSION MEDICINE, 2006, 16 (02) : 131 - 136
  • [2] Immune hemolytic anemia associated with negative routine serology
    Garratty, G
    [J]. SEMINARS IN HEMATOLOGY, 2005, 42 (03) : 156 - 164
  • [3] The James Blundell Award Lecture 2007: Do we really understand immune red cell destruction?
    Garratty, G.
    [J]. TRANSFUSION MEDICINE, 2008, 18 (06) : 321 - 334
  • [4] Autoimmune hemolytic anemia
    Gehrs, BC
    Friedberg, RC
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2002, 69 (04) : 258 - 271
  • [5] AUTOIMMUNE HEMOLYTIC-ANEMIA IN CHILDREN - REVIEW OF 80 CASES
    HABIBI, B
    HOMBERG, JC
    SCHAISON, G
    SALMON, C
    [J]. AMERICAN JOURNAL OF MEDICINE, 1974, 56 (01) : 61 - 69
  • [6] Kaplan H.S., 1985, Diagn. Med, V8, P29
  • [7] THE GEL TEST - A NEW WAY TO DETECT RED-CELL ANTIGEN-ANTIBODY REACTIONS
    LAPIERRE, Y
    RIGAL, D
    ADAM, J
    JOSEF, D
    MEYER, F
    GREBER, S
    DROT, C
    [J]. TRANSFUSION, 1990, 30 (02) : 109 - 113
  • [8] Comparison of conventional tube test technique and gel microcolumn assay for direct antiglobulin test: A large study
    Novaretti, MCZ
    Jens, E
    Pagliarini, T
    Bonifacio, SL
    Dorlhiac-Llacer, PE
    Chamone, DAF
    [J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2004, 18 (05) : 255 - 258
  • [9] AUTOIMMUNE HEMOLYTIC-ANEMIA ASSOCIATED WITH IGA - DIAGNOSTIC AND THERAPEUTIC ASPECTS IN A CASE WITH LONG-TERM FOLLOW-UP
    REUSSER, P
    OSTERWALDER, B
    BURRI, H
    SPECK, B
    [J]. ACTA HAEMATOLOGICA, 1987, 77 (01) : 53 - 56
  • [10] Vaccination-associated immune hemolytic anemia in two children
    Seltsam, A
    Shukry-Schulz, S
    Salama, A
    [J]. TRANSFUSION, 2000, 40 (08) : 907 - 909