Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway

被引：64

作者：

Li, Chengyun ^{[1
]}

Liang, Geyu ^{[1
]}

Yang, Sheng ^{[1
]}

Sui, Jing ^{[1
]}

Yao, Wenzhuo ^{[1
]}

Shen, Xian ^{[1
]}

Zhang, Yanqiu ^{[1
]}

Peng, Hui ^{[1
]}

Hong, Weiwei ^{[1
]}

Xu, Siyi ^{[1
]}

Wu, Wenjuan ^{[1
]}

Ye, Yancheng ^{[2
]}

Zhang, Zhiyi ^{[2
]}

Zhang, Wenhua ^{[2
]}

Yin, Lihong ^{[1
]}

Pu, Yuepu ^{[1
]}

机构：

[1] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing 210009, Jiangsu, Peoples R China

[2] Gansu Wuwei Tumor Hosp, Wuwei 733000, Gansu, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 55期

基金：

中国国家自然科学基金;

关键词：

gastric cancer; lncRNA; UCA1; progression; molecular mechanism; LONG NONCODING RNA; WESTERN-BLOT ASSAY; UCA1; CARCINOMA; EXPRESSION; RESISTANCE; INHIBITION; SURGERY; IDENTIFICATION; CELLS;

D O I：

10.18632/oncotarget.19281

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been recently shown to be dysregulated during disease occurrence and to play an important role in the progression of several cancers. However, the biological role and potential regulation mechanism of UCA1 in the carcinogenesis of gastric cancer remain unclear. In the present study, we found that UCA1 was aberrantly upregulated in gastric cancer tissues and gastric cancer cell lines, and was associated with TNM stage and metastasis. UCA1 silencing significantly inhibited gastric cancer BGC-823 cell proliferation and increased its apoptosis. We also found that UCA1 played an important role in the migration and invasion of gastric cancer cells in vitro and in vivo. The molecular mechanism of UCA1 suggested that UCA1 regulates the PI3KAkt-mTOR signaling proteins and their downstream mediators, to alter gastric cancer progression in vitro and in vivo. Collectively, the results showed a pivotal role of UCA1 in the tumorigenesis of gastric cancer. In addition, the study characterized a novel lncRNA-mRNA regulatory network, which may lead to a better understanding of the pathogenesis of gastric cancer and assist in lncRNA-directed diagnosis and therapy for this malignancy.

引用

页码：93476 / 93491

页数：16

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