Neutrophil and monocyte activation markers have prognostic impact in disseminated intravascular coagulation: In vitro effect of thrombin on monocyte CD163 shedding

被引：23
作者：
Chung, Soie [1 ]
Kim, Ji-Eun [2 ]
Park, Seungman [1 ]
Han, Kyou-Sup [1 ]
Kim, Hyun Kyung [1 ,2 ]
机构：
[1] Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul 110744, South Korea
[2] Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul 110744, South Korea
来源：
THROMBOSIS RESEARCH | 2011年 / 127卷 / 05期
关键词：
Soluble CD163; Neutrophil elastase; Monocyte volume distribution width; Neutrophil volume distribution width; Disseminated intravascular coagulation; SCAVENGER RECEPTOR CD163; SOLUBLE CD163; UP-REGULATION; EXPRESSION; PROTEIN; PLASMA; MACROPHAGES; PREDICTION; INFECTION; SEVERITY;
D O I：
10.1016/j.thromres.2010.12.021
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Monocyte and neutrophil activation occur during microvascular disturbance of disseminated intravascular coagulation (DIC). This study investigated the diagnostic and prognostic value of circulating neutrophil elastase (NE) and neutrophil volume distribution width (NDW) as neutrophil activation markers and circulating soluble CD163 (sCD163) and monocyte volume distribution width (MDW) as monocyte activation markers in 168 patients suspected of having DIC. The sCD163 provided significant diagnostic value. The prognostic value of sCD163 was comparable to that of D-dimer, but was dependent on other coagulation markers. In vitro, thrombin significantly induced sCD163 from monocytes upregulated with IL-10 or dexamethasone. NDW was an independent and powerful prognostic marker. MDW and NE did not provide diagnostic and prognostic power. Excessive thrombin during ongoing DIC induces florid secretion of CD163; sCD163 might therefore be a potential diagnostic and prognostic marker for DIC. NDW, a convenient parameter measured by an automated hematology analyzer, may be an independent prognostic parameter for DIC. (C) 2011 Elsevier Ltd. All rights reserved.
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收藏
页码：450 / 456
页数：7
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