Identification and imaging of the nerves responsible for erectile function in rat prostate, in vivo, using optical nerve stimulation and optical coherence tomography

被引：40

作者：

Fried, Nathaniel M. ^{[1
]}

Rais-Bahrami, Soroush ^{[2
]}

Lagoda, Gwen A. ^{[2
]}

Chuang, Ai-Ying ^{[3
]}

Su, Li-Ming ^{[2
]}

Burnett, Arthur L., III ^{[2
]}

机构：

[1] Univ N Carolina, Dept Phys & Opt Sci, Charlotte, NC 28223 USA

[2] Johns Hopkins Med Sch, Dept Urol, Baltimore, MD 21287 USA

[3] Johns Hopkins Med Sch, Dept Pathol, Baltimore, MD 21287 USA

来源：

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS | 2007年 / 13卷 / 06期

关键词：

laser biomedical applications; nervous system; thulium; urinary system;

D O I：

10.1109/JSTQE.2007.910119

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The cavernous nerves on the prostate surface are responsible for erectile function. Optical diagnostic tools such as optical coherence tomography and laser nerve stimulation may assist in the identification, imaging, and preservation of these microscopic nerves during prostate cancer surgery, and thus, help preserve sexual function after surgery. The feasibility of noncontact laser stimulation of the cavernous nerves is demonstrated in an in vivo rat prostate model with comparison to conventional electrical nerve stimulation. High-resolution optical coherence tomographic images of the nerves are also obtained and compared with histology. These optical technologies may be suitable as surgical guidance tools during laparoscopic and robotic nerve-sparing prostate cancer surgery.

引用

页码：1641 / 1645

页数：5

共 32 条

[1] Second prize:: 2006 endourological society essay competition -: Preliminary experience with the Niris™ optical coherence tomography system during laparoscopic and robotic prostatectomy [J].

Aron, Monish ;

Kaouk, Jihad H. ;

Hegarty, Nicholas J. ;

Colombo, Jose Roberto, Jr. ;

Haber, Georges-Pascal ;

Chung, Benjamin I. ;

Zhou, Ming ;

Gill, Inderbir S. .

JOURNAL OF ENDOUROLOGY, 2007, 21 (08) :814-818

[2]

Boppart S A, 2001, Comput Aided Surg, V6, P94, DOI 10.3109/10929080109145996

[3]

Bouma B. E., 2002, HDB OPTICAL COHERENC

[4] Erectile function outcome reporting after clinically localized prostate cancer treatment [J].

Burnett, Arthur L. ;

Aus, Gunnar ;

Canby-Hagino, Edith D. ;

Cookson, Michael S. ;

D'Amico, Anthony V. ;

Dmochowski, Roger R. ;

Eton, David T. ;

Forman, Jeffrey D. ;

Goldenberg, S. Larry ;

Hernandez, Javier ;

Higano, Celestia S. ;

Kraus, Stephen ;

Liebert, Monica ;

Moul, Judd W. ;

Tangen, Catherine ;

Thrasher, J. Brantley ;

Thompson, Ian .

JOURNAL OF UROLOGY, 2007, 178 (02) :597-601

[5]

BUSH J, 2000, P SOC PHOTO-OPT INS, V4204, P1

[6] Potency, continence and complication rates in 1,870 consecutive radical retropubic prostatectomies [J].

Catalona, WJ ;

Carvalhal, GF ;

Mager, DE ;

Smith, DS .

JOURNAL OF UROLOGY, 1999, 162 (02) :433-438

[7] Anatomical studies of the neurovascular bundle and cavernosal nerves [J].

Costello, AJ ;

Brooks, M ;

Cole, OJ .

BJU INTERNATIONAL, 2004, 94 (07) :1071-1076

[8] Optical diagnostics in urology: current applications and future prospects [J].

Crow, P ;

Stone, N ;

Kendall, CA ;

Persad, RA ;

Wright, MPJ .

BJU INTERNATIONAL, 2003, 92 (04) :400-407

[9] Optical coherence tomography as a method for identifying benign and malignant microscopic structures in the prostate gland [J].

D'Amico, AV ;

Weinstein, M ;

Li, XD ;

Richie, JP ;

Fujimoto, J .

UROLOGY, 2000, 55 (05) :783-787

[10]

Feldchtein F, 2006, J ENDOUROL, V20, pA198

← 1 2 3 4 →