Vaccines against COVID-19

被引：0
作者：
Fathi, Anahita [1 ,2 ,3 ]
Mellinghoff, Sibylle C. [1 ,3 ,4 ,5 ,6 ]
机构：
[1] Univ Klinikum Hamburg Eppendorf, Med Klin & Poliklin 1, Sekt Infektiol, Martinistr 52, D-20246 Hamburg, Germany
[2] Deutsch Zentrum Infekt Forsch DZIF, Hamburg, Germany
[3] Bernhard Nocht Inst Trop Med, Dept Clin Immunol Infect Dis, Hamburg, Germany
[4] Univ Cologne, Klin Innere Med 1, Exzellenzzentrum Med Mykol ECMM, Med Fak, Cologne, Germany
[5] Univ Cologne, Uniklinikum Koln, Cologne, Germany
[6] Deutsch Zentrum Infekt Forsch DZIF, Bonn, Germany
来源：
INTERNIST | 2021年 / 62卷 / 11期
关键词：
Vaccine development; SARS-CoV-2; Safety; Immunosuppression; Pregnancy; SEASONAL INFLUENZA; VACCINATION; CANCER;
D O I：
10.1007/s00108-021-01164-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The ongoing COVID-19 pandemic represents an emergency situation of devastating proportions. To mitigate its effects, several safe and effective vaccines have been developed in a very short period of time. Currently, four vaccines have been approved by the European Medicines Agency (EMA) and are in use in Germany. These include two mRNA vaccines and two vector-based vaccines. They all show very good protective efficacy, especially against severe courses of disease and can significantly contain the pandemic by reducing viral transmission. This article focuses on the development and mechanism of action of the vaccines, their safety and efficacy profile as well as indications for vaccination and current recommendations for the use of vaccines in special groups of people, such as convalescent, immunosuppressed and pregnant patients. Finally, currently open scientific questions are addressed.
引用
收藏
页码：1191 / 1201
页数：11
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