Green synthesized cerium oxide nanoparticle: A prospective drug against oxidative harm

被引：87

作者：

Dutta, Debanjan ^{[1
]}

Mukherjee, Riya ^{[1
]}

Patra, Mousumi ^{[1
]}

Banik, Milon ^{[1
]}

Dasgupta, Rakhi ^{[1
]}

Mukherjee, Manabendra ^{[2
]}

Basu, Tarakdas ^{[1
]}

机构：

[1] Univ Kalyani, Dept Biochem & Biophys, Kalyani 741235, W Bengal, India

[2] Saha Inst Nucl Phys, Kolkata 700064, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2016年 / 147卷

关键词：

Green synthesis; Cerium oxide nanoparticles; Aloe-vera extract; Anti-oxidant activity; Mouse neural cells; ULTRAVIOLET-ABSORPTION; REDOX STATE; NANOCRYSTALS; NANOCERIA; SURFACE; CEO2; NANOSTRUCTURES; SHIFT; SIZE; PH;

D O I：

10.1016/j.colsurfb.2016.07.045

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Cerium oxide nanoparticle (CeONP) of size 2-3 nm was synthesized by a new, simple and green method at ambient temperature, using cerium nitrate as prime precursor and Aloe vera leaf extract as stabilizing agent. Of the two oxidation states (+3) and (+4) of cerium, it was dominantly present in (+3) state in CeONP and cyclic conversion of Ce(III)O -> Ce(IV)O -> Ce(III)O by reaction with H2O2 implied uninterrupted antioxidant property of CeONP. Moreover, the higher oxygen defect in the crystal lattice produced particles with higher antioxidant activity. CeONP was found to neutralize the deleterious effects of H2O2 viz., cell death, generation of intracellular reactive oxygen species and loss of connectivity in mouse neural cells. Therefore, CeONP might have potential use in future as an anti-oxidant drug. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：45 / 53

页数：9

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