The Potential of the Marine Microalga Diacronema lutheri in the Prevention of Obesity and Metabolic Syndrome in High-Fat-Fed Wistar Rats

被引:11
|
作者
Mayer, Claire [1 ]
Come, Martine [1 ]
Ulmann, Lionel [1 ]
Martin, Isabelle [1 ]
Zittelli, Graziella Chini [2 ]
Faraloni, Cecilia [2 ]
Ouguerram, Khadija [3 ]
Chenais, Benoit [4 ]
Mimouni, Virginie [1 ]
机构
[1] Le Mans Univ, Dept Genie Biol, BiOSSE Biol Organisms Stress Hlth Environm, Inst Univ Technol, F-53020 Laval, France
[2] CNR, Inst BioEcon, Dept Biol, Agr & Food Sci, I-50019 Florence, Italy
[3] Nantes Univ, UMR1280 PhAN, Physiopathol Nutr Adaptat, INRAe,CHU Hotel Dieu,IMAD,CRNH Ouest, F-44000 Nantes, France
[4] Le Mans Univ, UFR Sci & Tech, Biol Organisms Stress Hlth Environm, BiOSSE, F-72085 Le Mans, France
来源
MOLECULES | 2022年 / 27卷 / 13期
关键词
Diacronema lutheri; metabolic syndrome; metabolic disturbances; n-3; LC-PUFA; obesity; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; ACID-COMPOSITION; ADIPOSE-TISSUE; NANNOCHLOROPSIS-OCULATA; DOCOSAHEXAENOIC ACID; ANTIOXIDANT ACTIVITY; ISOCHRYSIS-GALBANA; LIPID-METABOLISM; PAVLOVA-LUTHERI;
D O I
10.3390/molecules27134246
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Long-chain polyunsaturated fatty acids n-3 series (n-3 LC-PUFAs), especially eicosapentaenoic and docosahexaenoic acids, are known to exert preventive effects on obesity and metabolic syndrome. Mainly consumed in the form of fish oil, LC-PUFAs n-3 are also found in significant quantities in other sources such as certain microalgae. The aim of this study was to evaluate the effects of Diacronema lutheri (Dia), a microalga rich in n-3 LC-PUFAs, on metabolic disorders associated with obesity. Three groups of male Wistar rats (n = 6 per group) were submitted for eight weeks to a standard diet or high-fat and high-fructose diet (HF), supplemented or not with 12% of Dia (HF-Dia). Compared to HF rats, HF-Dia rats showed a 41% decrease in plasma triacylglycerol (TAG) and an increase in plasma cholesterol (+35%) as well as in high-density lipoprotein cholesterol (+51%) without change to low-density lipoprotein cholesterol levels. Although fasting glycemia did not change, glucose and insulin tolerance tests highlighted an improvement in glucose and insulin homeostasis. Dia supplementation restored body weight and fat mass, and decreased levels of liver TAG (-75%) and cholesterol (-84%). In HF-Dia rats, leptin was decreased (-30%) below the control level corresponding to a reduction of 68% compared to HF rats. Similarly, the anti-inflammatory cytokines interleukin-4 (IL-4) and IL-10 were restored up to control levels, corresponding to a 74% and 58% increase in HF rats, respectively. In contrast, the level of IL-6 remained similar in the HF and HF-Dia groups and about twice that of the control. In conclusion, these results indicated that the D. lutheri microalga may be beneficial for the prevention of weight gain and improvement in lipid and glucose homeostasis.
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页数:18
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