Studies on stereoselective electrophilic cyanation

被引：9
作者：
Buttke, K [1 ]
Niclas, HJ [1 ]
机构：
[1] Max Born Inst, D-12474 Berlin, Germany
来源：
JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1998年 / 340卷 / 07期
关键词：
D O I：
10.1002/prac.19983400712
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The enantioselective, electrophilic cyanation of the enolates of 2-substituted 1-tetralones 3 is described. Enantiomerically pure 2-cyanato-1,1'-binaphthyl derivatives 2, 6a and b are used as cyanating agents. The influence of solvent, temperature, additives and the method of enolate formation are investigated. Best results are obtained with 48% ee in the case of compound 2 and 60% ee in the case of compound 6b if the enolate is prepared from the corresponding silyl enol ether 7 and Toluene is used as solvent.
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页码：669 / 675
页数：7
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