Anti-Inflammatory Activities of Some Newly Synthesized Pyridinyl- and Indazolyl Benzamide Derivatives

被引：8
|
作者：
Hussain, Azza A. [1 ]
Abdulla, Mohamed M. [2 ]
Amr, Abd El-Gard E. [3 ,4 ]
Al-Omar, Mohamed A. [3 ]
Shalaby, Ahmed F. A. [1 ]
机构：
[1] Cairo Univ, Fac Sci, Dept Chem, Cairo, Egypt
[2] Saco Pharm Co, Res Unit, 6th October City 11632, Egypt
[3] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, DEDC, Riyadh 11451, Saudi Arabia
[4] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2015年 / 41卷 / 01期
关键词：
5-chloroanisic acid; aldehydes; N-substituted benzamides; anti-inflammatory activities; HETEROCYCLIC-COMPOUNDS; SELECTIVE-INHIBITION; RAT; VIRUS;
D O I：
10.1134/S106816201405015X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of substituted (pyridin-4-yl)phenyl-2-methoxybenzamide and their derivatives were prepared and screened for their anti-inflammatory activities. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. Some of the newly synthesized compounds exhibited better pharmacological and biological responses than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences.
引用
收藏
页码：87 / 96
页数：10
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