Behcet Disease Evolution of Clinical Manifestations

被引:125
作者
Ideguchi, Haruko [2 ]
Suda, Akiko [3 ]
Takeno, Mitsuhiro
Ueda, Atsuhisa
Ohno, Shigeru [2 ]
Ishigatsubo, Yoshiaki [1 ]
机构
[1] Yokohama City Univ, Grad Sch Med, Dept Internal Med & Clin Immunol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[2] Yokohama City Univ, Med Ctr, Ctr Rheumat Dis, Yokohama, Kanagawa 2360004, Japan
[3] Yokohama Minami Kyosai Hosp, Dept Rheumatol, Yokohama, Kanagawa, Japan
关键词
PREVALENCE; TURKEY; JAPAN; EPIDEMIOLOGY; INVOLVEMENT; MULTICENTER; SEX;
D O I
10.1097/MD.0b013e318211bf28
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Clinical phenotypes of Behcet disease (BD) vary among ethnic groups. We chronologically analyzed the clinical manifestations of BD in 412 patients meeting the Japanese criteria for BD seen at 2 Yokohama City University hospitals from July 1991 to December 2007. We examined the onset of individual symptoms in each patient. A single initial symptom appeared earlier than any other manifestation in 78% of the patients. Time from the initial symptom to diagnosis was 8.6 +/- 10.1 years. Oral ulcer, the most common initial manifestation, preceded the diagnosis by 7.5 +/- 10.2 years. Genital ulcer and eye and skin involvement appeared 1 or 2 years before diagnosis, whereas gastrointestinal, central nervous system, or vascular involvement developed later. The frequency of eye involvement was significantly higher in patients with neurologic lesions, but significantly lower in those with gastrointestinal or vascular involvement. However, no particular combination of major symptoms predicted the development of organ involvement. There has been a recent decrease in the rate of "complete'' BD (patients having all 4 of the major symptoms of oral ulcers, genital ulcers, and eye and skin lesions), whereas the frequencies of arthritis, gastrointestinal, and vascular involvement have been increasing. Further assessment may allow the detection of early predictors of the more aggressive disease, which requires more intensive treatment.
引用
收藏
页码:125 / 132
页数:8
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