Effect of propranolol on naming in chronic Broca's aphasia with anomia

被引：19
作者：
Beversdorf, David Q.
Sharma, Umesh K.
Phillips, Nicole N.
Notestine, Margaret A.
Slivka, Andrew P.
Friedman, Norman M.
Schneider, Sandra L.
Nagaraja, Haikady N.
Hillier, Ashleigh
机构：
[1] Ohio State Univ, Med Ctr, Dept Neurol, Columbus, OH 43210 USA
[2] Bond Clin, Winter Haven, FL USA
[3] Univ Washington, Dept Neurol, Seattle, WA 98195 USA
[4] Akron Gen Med Ctr, Akron, OH USA
[5] Vanderbilt Univ, Dept Speech & Hearing Sci, Nashville, TN USA
[6] Ohio State Univ, Gen Clin Res Ctr, Columbus, OH 43210 USA
[7] Ohio State Univ, Dept Stat, Columbus, OH 43210 USA
[8] Univ Massachusetts, Dept Psychol, Lowell, MA USA
来源：
NEUROCASE | 2007年 / 13卷 / 04期
关键词：
beta-adrenergic; stroke; aphasia; language; norepinephrine; propranolol;
D O I：
10.1080/13554790701595471
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task. Therefore, we tested naming in a pilot study of chronic Broca's aphasia patients with anomia after propranolol and after placebo in a double-blinded crossover manner. Naming was better after propranolol than after placebo, suggesting a potential benefit from propranolol in chronic Broca's aphasia with anomia. Larger follow-up studies are necessary to further investigate this effect.
引用
收藏
页码：256 / 259
页数：4
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