Promising alternative clinical uses of prostaglandin F2α analogs: Beyond the eyelashes

被引:28
作者
Choi, Young M. [1 ]
Diehl, Joseph [2 ]
Levins, Paul C. [2 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA
关键词
alopecia areata; androgenic alopecia; bimatoprost; glaucoma; latanoprost; prostaglandin; prostaglandin F2 alpha analog; travoprost; vitiligo; PATTERN ANDROGENETIC ALOPECIA; TOPICAL BIMATOPROST; LATANOPROST TREATMENT; IRIDIAL PIGMENTATION; OPHTHALMIC SOLUTION; IRIS PIGMENTATION; HUMAN MELANOCYTES; HAIR-GROWTH; AREATA; EFFICACY;
D O I
10.1016/j.jaad.2014.10.012
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Prostaglandin F2 alpha analogs, commonly prescribed for glaucoma treatment, have been shown to induce side effects such as cutaneous hypertrichosis and hyperpigmentation. Therefore, these medications have theoretic applications in the treatment of alopecia and disorders of hypopigmentation. We reviewed the literature to find original studies assessing the use of prostaglandin F2 alpha analogs in these settings. Studies and reports were analyzed in regards to androgenic alopecia, alopecia areata, chemotherapy-induced alopecia, vitiligo, and hypopigmented scarring. Based on the results of these studies, and consideration of pathophysiologic mechanism, the most promising applications for prostaglandin F2 alpha analogs include androgenic alopecia, chemotherapy- induced alopecia, and alopecia areata concurrently treated with corticosteroids.
引用
收藏
页码:712 / 716
页数:5
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