The 5-HT1A agonist 8-OH-DPAT increases the number of spike-wave discharges in a genetic rat model of absence epilepsy

被引：38

作者：

Gerber, K

Filakovszky, J

Halasz, P

Bagdy, G

机构：

[1] Natl Inst Psychiat & Neurol, Lab Neurochem & Expt Med, H-1021 Budapest, Hungary

[2] Haynal Umre Univ Hlth Sci, Natl Inst Psychiat & Neurol, Dept Neurol, Budapest, Hungary

来源：

BRAIN RESEARCH | 1998年 / 807卷 / 1-2期

基金：

匈牙利科学研究基金会;

关键词：

absence epilepsy; WAG/RIJ rat; serotonin; 8-hydrox-2-(di-n-propylamin)-tetralin (8-OH-DPAT); spike-wave discharge; 5-HT1A receptor;

D O I：

10.1016/S0006-8993(98)00801-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on the epileptiform activity has been investigated in adult WAG/RIJ rats. Either intraperitoneal (0.1-0.5 mg/kg) or intracerebroventricular (2-20 mu g/rat) administration of 8-OH-DPAT caused marked, dose-dependent increases in the number and mean cumulative duration of spike-wave discharges. These effects were attenuated by NAN-190, a 5-HT1A receptor antagonist. These data indicate that serotonergic system regulates the epileptiform activity in this genetic model of human absence epilepsy. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：243 / 245

页数：3

共 15 条

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