Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells

被引：34

作者：

Akagi, T

Usuda, M

Matsuda, T

Ko, MSH

Niwa, H

Asano, M

Koide, H

Yokota, T

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Stem Cell Biol, Kanazawa, Ishikawa 9208640, Japan

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[3] NIA, Genet Lab, NIH, Baltimore, MD 21224 USA

[4] RIKEN, Ctr Dev Biol, Lab Pluripotent Cell Studies, Kobe, Hyogo 6500047, Japan

[5] Kanazawa Univ, Adv Res Ctr, Inst Expt Anim, Kanazawa, Ishikawa 9208640, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 331卷 / 01期

关键词：

ES cells; STAT3; Oct-3/4; Zfp-57; self-renewal; targeted disruption; RNAi;

D O I：

10.1016/j.bbrc.2005.03.118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts. Transcription factor STAT3 is essential for the self-renewal of ES cells. In this study, we searched for downstream molecules of STAT3 in ES cells. Using DNA chip analysis, we obtained zinc finger protein (Zfp)-57. The expression of Zfp-57 was restricted to undifferentiated ES cells and activation of STAT3 led to expression of Zfp-57. We also found that forced expression of a dominant-negative mutant of STAT3 or repression of Oct-3/4 expression led to down-regulation of Zfp-57. Targeted disruption of Zfp-57 resulted in no gross phenotypical defects, including expression of undifferentiated-state-specific genes. These data suggest that Zfp-57 is a downstream molecule of STAT3 and Oct-3/4 in ES cells, although dispensable for their self-renewal. (c) 2005 Elsevier Inc. All rights reserved.

引用

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页码：23 / 30

页数：8

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