The biological chemistry of lead

被引：306
作者：
Godwin, HA [1 ]
机构：
[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 02期
关键词：
D O I：
10.1016/S1367-5931(00)00194-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent biophysical studies on the interactions between lead and recombinant proteins and peptides that naturally bind zinc or calcium have provided unparalleled insights into the biological chemistry and molecular toxicology of lead. These studies lay the foundation for the rational design of improved methods for detecting and treating lead poisoning.
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收藏
页码：223 / 227
页数：5
相关论文
共 47 条
  • [1] BOUTON CML, 2001, IN PRESS J NEUROCHEM
  • [2] Molecular mechanisms of lead neurotoxicity
    Bressler, J
    Kim, K
    Chakraborti, T
    Goldstein, G
    [J]. NEUROCHEMICAL RESEARCH, 1999, 24 (04) : 595 - 600
  • [3] Lead poisoning and the inactivation of 5-aminolevulinate dehydratase as modeled by the tris(2-mercapto-1-phenylimidazolyl)hydroborato lead complex, {[TmPh]Pb}[ClO4]
    Bridgewater, BM
    Parkin, G
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (29) : 7140 - 7141
  • [4] Exploring the new world of the genome with DNA microarrays
    Brown, PO
    Botstein, D
    [J]. NATURE GENETICS, 1999, 21 (Suppl 1) : 33 - 37
  • [5] Centers for disease control and prevention, 1997, screening young children for lead poisoning
  • [6] Christensen J. M., 1994, Handbook of Metals in Clinical and Analytical Chemistry, P425
  • [7] A selective, ratiometric fluorescent sensor for Pb2+
    Deo, S
    Godwin, HA
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (01) : 174 - 175
  • [8] Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    Donovan, A
    Brownlie, A
    Zhou, Y
    Shepard, J
    Pratt, SJ
    Moynihan, J
    Paw, BH
    Drejer, A
    Barut, B
    Zapata, A
    Law, TC
    Brugnara, C
    Kingsley, PD
    Palis, J
    Fleming, MD
    Andrews, NC
    Zon, LI
    [J]. NATURE, 2000, 403 (6771) : 776 - 781
  • [9] Ionomycin, a carboxylic acid ionophore, transports Pb2+ with high selectivity
    Erdahl, WL
    Chapman, CJ
    Taylor, RW
    Pfeiffer, DR
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (10) : 7071 - 7079
  • [10] X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase
    Erskine, PT
    Senior, N
    Awan, S
    Lambert, R
    Lewis, G
    Tickle, LJ
    Sarwar, M
    Spencer, P
    Thomas, P
    Warren, MJ
    ShoolinginJordan, PM
    Wood, SP
    Cooper, JB
    [J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (12) : 1025 - 1031
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