Coating Optimization of Superparamagnetic Iron Oxide Nanoparticles for High T2 Relaxivity

被引：362
作者：
Tong, Sheng
Hou, Sijian
Zheng, Zhilan
Zhou, Jun
Bao, Gang [1 ]
机构：
[1] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA
来源：
NANO LETTERS | 2010年 / 10卷 / 11期
基金：
美国国家卫生研究院;
关键词：
SPIO; MRI contrast agent; nuclear relaxation; molecular imaging; MAGNETIC NANOPARTICLES; CONTRAST AGENTS; NANOCRYSTALS; MRI; ANGIOGENESIS; EXCHANGE; DELIVERY; SIZE;
D O I：
10.1021/nl102623x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by One-tuning the core size and PEG coating of SPIOs, the T-2 relaxivity per particle can be increased by >200-Fold. With 14 nm core and PEG1000 coating, SPIOs can have T-2 relaxivity of 385 s(-1) mM(-1), which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.
引用
收藏
页码：4607 / 4613
页数：7
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