Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling

被引：57

作者：

Melcher, Karsten ^{[1
]}

Zhou, X. Edward ^{[1
]}

Xu, H. Eric ^{[1
]}

机构：

[1] Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2010年 / 20卷 / 06期

关键词：

ACTIVATED PROTEIN-KINASES; PHOSPHATASE; 2C; HYDROGEN-PEROXIDE; GUARD-CELLS; ARABIDOPSIS; ABA; IDENTIFICATION; INTERACTS; TRANSDUCTION; AGRICULTURE;

D O I：

10.1016/j.sbi.2010.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abscisic acid (ABA) is a plant hormone with important functions in stress protection and physiology. Recently, the PYR/PYL/RCAR family of intracellular ABA receptors was identified. These receptors directly link ABA perception to a canonical ABA signaling pathway, in which ABA-bound receptors bind and inhibit type 2C phosphatases. High resolution crystal structures of members of this family have been solved in all relevant states: as apo receptors, bound to ABA, and as receptor-ABA-phosphatase complexes. Together, these structures provide a detailed gate-latch-lock mechanism of ABA recognition, receptor-PP2C interaction, and inhibition of the PP2C phosphatase activity and provide a basis for the design of synthetic ABA agonists for stress protection of crop plants.

引用

页码：722 / 729

页数：8

共 41 条

[21] A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors [J].

Melcher, Karsten ;

Ng, Ley-Moy ;

Zhou, X. Edward ;

Soon, Fen-Fen ;

Xu, Yong ;

Suino-Powell, Kelly M. ;

Park, Sang-Youl ;

Weiner, Joshua J. ;

Fujii, Hiroaki ;

Chinnusamy, Viswanathan ;

Kovach, Amanda ;

Li, Jun ;

Wang, Yonghong ;

Li, Jiayang ;

Peterson, Francis C. ;

Jensen, Davin R. ;

Yong, Eu-Leong ;

Volkman, Brian F. ;

Cutler, Sean R. ;

Zhu, Jian-Kang ;

Xu, H. Eric .

NATURE, 2009, 462 (7273) :602-U72

[22] Structural basis of abscisic acid signalling [J].

Miyazono, Ken-ichi ;

Miyakawa, Takuya ;

Sawano, Yoriko ;

Kubota, Keiko ;

Kang, Hee-Jin ;

Asano, Atsuko ;

Miyauchi, Yumiko ;

Takahashi, Mihoko ;

Zhi, Yuehua ;

Fujita, Yasunari ;

Yoshida, Takuya ;

Kodaira, Ken-Suke ;

Yamaguchi-Shinozaki, Kazuko ;

Tanokura, Masaru .

NATURE, 2009, 462 (7273) :609-U79

[23] Three Arabidopsis SnRK2 Protein Kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, Involved in ABA Signaling are Essential for the Control of Seed Development and Dormancy [J].

Nakashima, Kazuo ;

Fujita, Yasunari ;

Kanamori, Norihito ;

Katagiri, Takeshi ;

Umezawa, Taishi ;

Kidokoro, Satoshi ;

Maruyama, Kyonoshin ;

Yoshida, Takuya ;

Ishiyama, Kanako ;

Kobayashi, Masatomo ;

Shinozaki, Kazuo ;

Yamaguchi-Shinozaki, Kazuko .

PLANT AND CELL PHYSIOLOGY, 2009, 50 (07) :1345-1363

[24] Structural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1 [J].

Nishimura, Noriyuki ;

Hitomi, Kenichi ;

Arvai, Andrew S. ;

Rambo, Robert P. ;

Hitomi, Chiharu ;

Cutler, Sean R. ;

Schroeder, Julian I. ;

Getzoff, Elizabeth D. .

SCIENCE, 2009, 326 (5958) :1373-1379

[25] Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins [J].

Park, Sang-Youl ;

Fung, Pauline ;

Nishimura, Noriyuki ;

Jensen, Davin R. ;

Fujii, Hiroaki ;

Zhao, Yang ;

Lumba, Shelley ;

Santiago, Julia ;

Rodrigues, Americo ;

Chow, Tsz-Fung F. ;

Alfred, Simon E. ;

Bonetta, Dario ;

Finkelstein, Ruth ;

Provart, Nicholas J. ;

Desveaux, Darrell ;

Rodriguez, Pedro L. ;

McCourt, Peter ;

Zhu, Jian-Kang ;

Schroeder, Julian I. ;

Volkman, Brian F. ;

Cutler, Sean R. .

SCIENCE, 2009, 324 (5930) :1068-1071

[26] Structural basis for selective activation of ABA receptors [J].

Peterson, Francis C. ;

Burgie, E. Sethe ;

Park, Sang-Youl ;

Jensen, Davin R. ;

Weiner, Joshua J. ;

Bingman, Craig A. ;

Chang, Chia-En A. ;

Cutler, Sean R. ;

Phillips, George N., Jr. ;

Volkman, Brian F. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (09) :1109-+

[27] The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands [J].

Radauer, Christian ;

Lackner, Peter ;

Breiteneder, Heimo .

BMC EVOLUTIONARY BIOLOGY, 2008, 8 (1)

[28] ABA perception and signalling [J].

Raghavendra, Agepati S. ;

Gonugunta, Vijay K. ;

Christmann, Alexander ;

Grill, Erwin .

TRENDS IN PLANT SCIENCE, 2010, 15 (07) :395-401

[29] Triple Loss of Function of Protein Phosphatases Type 2C Leads to Partial Constitutive Response to Endogenous Abscisic Acid [J].

Rubio, Silvia ;

Rodrigues, Americo ;

Saez, Angela ;

Dizon, Marie B. ;

Galle, Alexander ;

Kim, Tae-Houn ;

Santiago, Julia ;

Flexas, Jaume ;

Schroeder, Julian I. ;

Rodriguez, Pedro L. .

PLANT PHYSIOLOGY, 2009, 150 (03) :1345-1355

[30] The abscisic acid receptor PYR1 in complex with abscisic acid [J].

Santiago, Julia ;

Dupeux, Florine ;

Round, Adam ;

Antoni, Regina ;

Park, Sang-Youl ;

Jamin, Marc ;

Cutler, Sean R. ;

Luis Rodriguez, Pedro ;

Marquez, Jose Antonio .

NATURE, 2009, 462 (7273) :665-U143

← 1 2 3 4 5 →