Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling

被引：57
作者：
Melcher, Karsten [1 ]
Zhou, X. Edward [1 ]
Xu, H. Eric [1 ]
机构：
[1] Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2010年 / 20卷 / 06期
关键词：
ACTIVATED PROTEIN-KINASES; PHOSPHATASE; 2C; HYDROGEN-PEROXIDE; GUARD-CELLS; ARABIDOPSIS; ABA; IDENTIFICATION; INTERACTS; TRANSDUCTION; AGRICULTURE;
D O I：
10.1016/j.sbi.2010.09.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abscisic acid (ABA) is a plant hormone with important functions in stress protection and physiology. Recently, the PYR/PYL/RCAR family of intracellular ABA receptors was identified. These receptors directly link ABA perception to a canonical ABA signaling pathway, in which ABA-bound receptors bind and inhibit type 2C phosphatases. High resolution crystal structures of members of this family have been solved in all relevant states: as apo receptors, bound to ABA, and as receptor-ABA-phosphatase complexes. Together, these structures provide a detailed gate-latch-lock mechanism of ABA recognition, receptor-PP2C interaction, and inhibition of the PP2C phosphatase activity and provide a basis for the design of synthetic ABA agonists for stress protection of crop plants.
引用
收藏
页码：722 / 729
页数：8
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