Neuropathology in multiple sclerosis: new concepts

被引:94
作者
Lassmann, H [1 ]
机构
[1] Univ Vienna, Neurol Inst, Vienna, Austria
关键词
multiple sclerosis; pathology; demyelination; axon; oligodendrocyte;
D O I
10.1191/135245898678909367
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Multiple sclerosis lesions ore characterized by inflammation, demyelination and a variable degree of oxonol loss. The Patterns of inflammation in MS lesions ore compatible with a T-lymphocyte mediated immune reaction. The formation of demyelinated plaques, however, seem to require additional immunological mechanisms. In this review evidence is discussed for a pathogenetic role of demyelinating antibodies, toxic macrophage products, cytotoxic T-cells as well as metabolic disturbances of oligodendrocytes. It is suggested that the pathological heterogeneity regarding the patterns and extent of demyelination, remyelination and axonal loss may be the outcome of variable dominant immunopathogenetic mechanisms in different multiple sclerosis patients.
引用
收藏
页码:93 / 98
页数:6
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